Cholesteryl ester transfer and cholesterol esterification in type 1 diabetes: relationships with plasma glucose

被引：0

作者：

C.-K. Chang

T.K. Tso

J.T. Snook

Y.-S. Huang

R.A. Lozano

W.B. Zipf

机构：

[1] OSU Nutrition Program,

[2] Ohio State University,undefined

[3] 1787 Neil Avenue,undefined

[4] Columbus,undefined

[5] OH 43210,undefined

[6] USA,undefined

[7] Department of Nutrition and Health Science,undefined

[8] Fooyin Institute of Technology,undefined

[9] Kaohsiung,undefined

[10] Taiwan,undefined

[11] Department of Food and Nutrition,undefined

[12] Shih Chien University,undefined

[13] Taipei,undefined

[14] Taiwan,undefined

[15] Medical Nutritional R&D,undefined

[16] Ross Products Divison,undefined

[17] Abbott Laboratories,undefined

[18] Columbus OH,undefined

[19] USA,undefined

[20] Columbus Children's Hospital,undefined

[21] Columbus,undefined

[22] OH,undefined

[23] USA,undefined

来源：

Acta Diabetologica | 2001年 / 38卷

关键词：

Key words Type 1 (insulin-dependent) diabetes mellitus; Cholesteryl ester transfer protein; Lecithin: cholesterol acyltransferase; Plasma glucose;

D O I：

暂无

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学科分类号：

摘要：

The activities of two crucial enzymes of reverse cholesterol transport, cholesterol ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT), and their relationships with lipid profile and fasting plasma glucose were examined in 35 type 1 diabetic children. The CETP and LCAT activities were significantly lower (p<0.05) in the 4 subjects with normal fasting plasma glucose levels (<6.39 mmol/l) than in the 28 with high plasma glucose levels (CEPT activity, 10.63±3.81 vs. 32.18±13.94 nmol/ml h; LCAT activity, 25.52±4.53 vs. 39.52±12.52 nmol/ml h; both p<0.05). The subjects with high plasma glucose levels also had higher total and LDL-cholesterol than those with normal glucose levels. CETP activity was positively correlated with fasting plasma glucose, CETP concentration, LCAT activity, total cholesterol, free cholesterol, LDL-C, and LDL-cholesterol ester, while negatively correlated with cholesteryl ester to free cholesterol ratio, LDL triglyceride to protein ratio, and LDL triglyceride to cholesteryl ester ratio. LCAT activity was found to positively correlate with CETP activity, total cholesterol, free cholesterol. LDL-C, CETP concentration, and LDL-cholesteryl ester, while it negatively correlated with cholesteryl ester to free cholesterol ratio. The results observed in type 1 diabetic subjects suggest that (1) accelerated LCAT and CETP activities may result in the accumulation of LDL-cholesteryl ester; and (2) fasting plasma glucose may be a major determinant of CETP activity.

引用

页码：37 / 42

页数：5