Intra-abdominal adiposity, inflammation, and cardiovascular risk: New insight in the global cardiometabolic risk

被引：4
作者：
Calabro P. [1 ]
Yeh E.T.H. [1 ]
机构：
[1] Division of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples, Naples
来源：
Current Cardiovascular Risk Reports | 2007年 / 1卷 / 1期
关键词：
Obesity; Adipose Tissue; Adiponectin Concentration; Serum Resistin Level; Coronary Artery Smooth Muscle Cell;
D O I：
10.1007/s12170-007-0006-8
中图分类号：
学科分类号：
摘要：
Increasing evidence supports the role of adipose tissue in the development of a systemic inflammatory state, which contributes to obesity-associated vasculpathy and cardiovascular risk. In addition to storing calories as triglycerides, adipocytes secrete a large variety of proteins, including cytokines, chemokines, and hormone-like factors (eg, leptin, adiponectin, resistin). This production of pro chemokines by adipose tissue is of particular interest, because their local secretion by perivascular adipose depots may provide a new mechanistic link between obesity and its associated vascular complications. Insulin resistance, in subjects with or without diabetes, is frequently associated with obesity, particularly with an excess of intra-abdominal fat. Recently, the endocannabinoid system, among others, has been shown to be involved in the pathophysiology of visceral obesity and global cardiometabolic risk, as represented by the overall risk of developing type 2 diabetes or cardiovascular diseases. © 2007 Current Medicine Group LLC.
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页码：32 / 38
页数：6
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