The Leading Role of Membrane Ca2+-ATPase in Recovery of Ca2+ Homeostasis after Glutamate Shock

被引：0
作者：
T. P. Storozhevykh
V. G. Pinelis
N. P. Vinskaya
A. M. Surin
B. I. Khodorov
机构：
[1] Russian Academy of Medical Sciences,Laboratory of Membranology, Research Center of Children Health
[2] Institute of General Pathology and Pathological Physiology,Russian Academy of Medical Sciences
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 135卷
关键词：
neuron; glutamate; neurotoxicity; Ca; -ATPase; Na; /Ca; -exchange;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Combined blockade of Na+/Ca2+ exchange, Ca2+ uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca2+ after 1-min action of glutamate (100 μM) or K+ (50 mM). However, replacement of Ca2+ with Ba2+, which cannot be transported by Ca2+-ATPase, considerably delayed the decrease in intracellular Ba2+ after its rise caused by glutamate or potassium application in all examined cells, which attest to an important role of Ca2+-ATPase in Ca2+ extrusion after the action of glutamate or K+.
引用
收藏
页码：139 / 142
页数：3
相关论文
共 37 条
  • [1] Khodorov B. I.(2001)undefined Biol. Membr. 18 421-432
  • [2] Storozhevykh T. P.(1988)undefined J. Physiol. 399 247-266
  • [3] Surin A. M.(1988)undefined TINS 11 438-441
  • [4] Ascher P.(1997)undefined J. Gen. Physiol. 109 41-51
  • [5] Nowak L.(1988)undefined Biochim. Biophys. Acta 947 549-569
  • [6] Blaustein M. P.(1982)undefined Biochemistry 21 4511-4516
  • [7] Condresku M.(1996)undefined Brain Res. Mol. Brain Res. 36 93-100
  • [8] Chernaya G.(1993)undefined FEBS Lett. 324 271-273
  • [9] Kalaria V.(1995)undefined FEBS Lett. 371 249-252
  • [10] Reeves J. P.(1994)undefined Neuron 12 295-300
1234