A multicenter double-blind randomized crossover study comparing the impact of dorsal subthalamic nucleus deep brain stimulation versus standard care on apathy in Parkinson’s disease: a study protocol

[1] Odekerken VJ(2013)Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial Lancet Neurol 12 37-44

[2] van Laar T(2003)Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease N Engl J Med 349 1925-1934

[3] Staal MJ(2018)Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson’s disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial Lancet Neurol 17 223-231

[4] Mosch A(2021)Apathy induced by subthalamic nucleus deep brain stimulation in Parkinson’s disease: a meta-analysis Mov Disord 36 317-326

[5] Hoffmann CF(2013)Apathy in Parkinson’s disease: diagnosis, neuropsychological correlates, pathophysiology and treatment Behav Neurol 27 501-513

[6] Nijssen PC(2016)Postoperative apathy can neutralise benefits in quality of life after subthalamic stimulation for Parkinson’s disease J Neurol Neurosurg Psychiatry 87 311-318

[7] Krack P(2014)Stimulation of the subthalamic area modulating movement and behavior Parkinsonism Relat Disord 20 1298-1300

[8] Batir A(2018)Deep brain stimulation for patients with Parkinson’s disease: effect on caregiver burden Neurologia 33 154-159

[9] Van Blercom N(2015)Apathy in Parkinson’s disease: clinical features, neural substrates, diagnosis, and treatment Lancet Neurol 14 518-531

[10] Chabardes S(2008)The nosological position of apathy in clinical practice J Neurol Neurosurg Psychiatry 79 1088-1092

[1] Odekerken VJ(2013)Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial Lancet Neurol 12 37-44

[2] van Laar T(2003)Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease N Engl J Med 349 1925-1934

[3] Staal MJ(2018)Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson’s disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial Lancet Neurol 17 223-231

[4] Mosch A(2021)Apathy induced by subthalamic nucleus deep brain stimulation in Parkinson’s disease: a meta-analysis Mov Disord 36 317-326

[5] Hoffmann CF(2013)Apathy in Parkinson’s disease: diagnosis, neuropsychological correlates, pathophysiology and treatment Behav Neurol 27 501-513

[6] Nijssen PC(2016)Postoperative apathy can neutralise benefits in quality of life after subthalamic stimulation for Parkinson’s disease J Neurol Neurosurg Psychiatry 87 311-318

[7] Krack P(2014)Stimulation of the subthalamic area modulating movement and behavior Parkinsonism Relat Disord 20 1298-1300

[8] Batir A(2018)Deep brain stimulation for patients with Parkinson’s disease: effect on caregiver burden Neurologia 33 154-159

[9] Van Blercom N(2015)Apathy in Parkinson’s disease: clinical features, neural substrates, diagnosis, and treatment Lancet Neurol 14 518-531

[10] Chabardes S(2008)The nosological position of apathy in clinical practice J Neurol Neurosurg Psychiatry 79 1088-1092