Zebrafish as a model to study live mucus physiology

被引：0
作者：
Irena Jevtov
Tore Samuelsson
Grace Yao
Adam Amsterdam
Katharina Ribbeck
机构：
[1] Massachusetts Institute of Technology,Department of Biological Engineering
[2] Institute of Biomedicine,Department of Medical Biochemistry and Cell Biology
[3] Sahlgrenska Academy at University of Gothenburg,undefined
[4] David H. Koch Institute for Integrative Cancer Research,undefined
[5] Massachusetts Institute of Technology,undefined
来源：
Scientific Reports | / 4卷
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摘要：
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
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[1]  
Amerongen AV(1995)Salivary mucins: protective functions in relation to their diversity Glycobiology 5 733-740
[2]  
Bolscher JG(2009)The cervical mucus plug: structured review of the literature Acta Obstet Gynecol Scand 88 502-513
[3]  
Veerman EC(2009)Barrier properties of mucus Adv Drug Deliver Rev 61 75-85
[4]  
Becher N(1979)Mucins in the human gastrointestinal epithelium: a review Investigative & cell pathology 2 195-216
[5]  
Adams Waldorf K(2004)Mucins in cancer: protection and control of the cell surface Nat Rev Cancer 4 45-60
[6]  
Hein M(2008)Mucins in the mucosal barrier to infection Mucosal Immunol 1 183-197
[7]  
Uldbjerg N(2011)Mucin dynamics and enteric pathogens Nat Rev Microbiol 9 265-278
[8]  
Cone RA(2006)Sperm transport in the female reproductive tract Hum Reprod Update 12 23-37
[9]  
Filipe MI(2000)Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease Gut 47 589-594
[10]  
Hollingsworth MA(2008)Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis PLoS Med 5 e54-28
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