Spotlight on Amisulpride in Schizophrenia

被引：0
作者：
Monique P. Curran
Caroline M. Perry
机构：
[1] Adis International Limited,
来源：
CNS Drugs | 2002年 / 16卷
关键词：
Schizophrenia; Haloperidol; Risperidone; Negative Symptom; Brief Psychiatric Rate Scale;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Amisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic. At low doses, it enhances dopaminergic neurotransmission by preferentially blocking presynaptic dopamine D2/D3 autoreceptors. At higher doses, amisulpride antagonises postsynaptic D2 and D3 receptors, preferentially in the limbic system rather than the striatum, thereby reducing dopaminergic transmission.
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页码：207 / 211
页数：4
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