B-type natriuretic peptide levels and benign adiposity in obese heart failure patients

被引:0
作者
Vasiliki Katsi
Maria Marketou
Alexios S. Antonopoulos
Dimitrios Vrachatis
Fragkiskos Parthenakis
Dimitris Tousoulis
机构
[1] Athens Medical School,1st Cardiology Department, Hippokration General Hospital
[2] University of Crete,Cardiology Department, Heraklion University Hospital
[3] School of Medicine,undefined
来源
Heart Failure Reviews | 2019年 / 24卷
关键词
Natriuretic peptides; Obesity; Heart failure; Body mass index;
D O I
暂无
中图分类号
学科分类号
摘要
Obesity is a major risk factor for the development of chronic heart failure (CHF) and does not only pose diagnostic challenges, but also has prognostic implications for these patients. Paradoxically, obese patients with CHF have a better prognosis than thinner individuals. In recent years, it has been demonstrated that the adipose tissue, even in patients with HF, is not always detrimental, and that obesity may coexist with a phenotype of benign adiposity without systemic metabolic abnormalities. Experimental data have shown that natriuretic peptides (NPs), and in particular brain natriuretic peptide (BNP), play a major role in the communication of the heart with the adipose tissue. Body fat distribution and adipose tissue function show a large degree of heterogeneity among depots and may explain the complex relationship between NPs and body fat. NPs can affect both the quality and the behaviour of fatty tissue, promoting a healthy adipocyte phenotype, and can favourably affect body fat metabolism. In this article, we review the existing literature on the bidirectional effects of BNP and adipose tissue in HF and highlight the complexity of this relationship.
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页码:219 / 226
页数:7
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共 532 条
  • [71] Vasan RS(2011)Relation of Visceral adiposity to circulating natriuretic peptides in ambulatory individuals Am J Cardiol 108 979-929
  • [72] von Haehling S(2006)Influence of body fat content and distribution on variation in metabolic risk J Clin Endocrinol Metab 91 4459-401
  • [73] Anker SD(2008)Body composition, insulin sensitivity, and cardiovascular disease profile in healthy Europeans Obesity (Silver Spring) 16 2696-748
  • [74] Evans WJ(2004)Regional body composition changes exhibit opposing effects on coronary heart disease risk factors Arterioscler Thromb Vasc Biol 24 923-1488
  • [75] Morley JE(2011)Epicardial fat volume in patients with left ventricular systolic dysfunction Am J Cardiol 108 397-undefined
  • [76] Argilés J(2015)Relation of epicardial fat thickness to the severity of heart failure in patients with nonischemic dilated cardiomyopathy Echocardiography 32 740-undefined
  • [77] Bales C(2016)2016 ACC/AHA/HFSA focused update on new pharmacological therapy for heart failure: an update of the 2013 ACCF/AHA guideline for the Management of Heart Failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America J Am Coll Cardiol 68 1476-undefined
  • [78] Baracos V(undefined)undefined undefined undefined undefined-undefined
  • [79] Guttridge D(undefined)undefined undefined undefined undefined-undefined
  • [80] Jatoi A(undefined)undefined undefined undefined undefined-undefined