Macrophages in neovascular age-related macular degeneration: friends or foes?

被引：0
作者：
J M Skeie
R F Mullins
机构：
[1] Carver Family Center for Macular Degeneration,Department of Ophthalmology and Visual Sciences
[2] The University of Iowa,Department of Biomedical Engineering
[3] The University of Iowa,undefined
来源：
Eye | 2009年 / 23卷
关键词：
macular degeneration; macrophage; choroid; angiogenesis; inflammation; animal model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The events that lead to choroidal neovascularization in eyes with age-related macular degeneration are poorly understood. One possibility that has been explored in a number of studies is that macrophages can promote neovascular changes. In this paper, we summarize the evidence for inflammation in general and macrophages in particular in pathologic neovascularization, and discuss how the diverse functions of these cells may promote or inhibit macular disease. We also discuss some of the conflicting findings regarding the role of macrophages in experimental choroidal neovascularization in mouse models, and suggest areas for future research.
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页码：747 / 755
页数：8
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