Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality

被引：0

作者：

Leisheng Zhang

Ying Chi

Yimeng Wei

Wenxia Zhang

Fuxu Wang

Lei Zhang

Linglin Zou

Baoquan Song

Xing Zhao

Zhongchao Han

机构：

[1] Chinese Academy of Medical Sciences & Peking Union Medical College,State Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital

[2] Guizhou Medical University,National Joint Local Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Key Laboratory of Adult Stem Cell Translational Research (Chinese Academy of Me

[3] Health-Biotech (Tianjin) Stem Cell Research Institute Co.,Precision Medicine Division

[4] Ltd.,Department of Neurosurgery

[5] The First Affiliated Hospital & Qianfoshan Hospital of Shandong First Medical University,Department of Hematology

[6] The Second Hospital of Hebei Medical University,Department of oncology

[7] Affiliated Hospital of Southwest Medical University,National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology

[8] The First Affiliated Hospital of Soochow University,undefined

来源：

Stem Cell Research & Therapy | / 12卷

关键词：

Acute myeloid leukemia (AML); BM-MSCs; Cellular vitality; Genomic variation; JAK-STAT signaling;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 297 条

[1]

Geyh S(2016)Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia Leukemia 30 683-691

[2]

Rodriguez-Paredes M(2016)Acute myeloid leukemia: a comprehensive review and 2016 update Blood Cancer J 6 158-173

[3]

Jager P(2020)The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML Nat Rev Cancer 20 1069-1078

[4]

Khandanpour C(2017)Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients Leukemia 31 1552-1564

[5]

Cadeddu RP(2020)Immune escape and immunotherapy of acute myeloid leukemia J Clin Invest 130 56-774

[6]

Gutekunst J(2017)Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor D-1-methyl-tryptophan J Hematol Oncol 10 765-513

[7]

Wilk CM(2017)An update clinical application of amniotic fluid-derived stem cells (AFSCs) in cancer cell therapy and tissue engineering Artif Cells Nanomed Biotechnol 45 6-228

[8]

Fenk R(2021)Two-step generation of mesenchymal stem/stromal cells from human pluripotent stem cells with reinforced efficacy upon osteoarthritis rabbits by HA hydrogel Cell Biosci 11 354-433

[9]

Zilkens C(2019)Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease Stem Cell Res Ther 10 497-93

[10]

Hermsen D(2018)MSX2 initiates and accelerates mesenchymal stem/stromal cell specification of hPSCs by regulating TWIST1 and PRAME Stem Cell Rep 11 216-1304

← 1 2 3 4 5 6 7 8 9 10 →