Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937

[1] Hanno R(1980)Methotrexate in psoriasis. A brief review of indications, usage, and complications of methotrexate therapy J Am Acad Dermatol 2 171-174

[2] Gruber GG(2000)Methotrexate use in rheumatoid arthritis. A clinician’s perspective Immunopharmacology 47 259-271

[3] Owen LG(1983)The pharmacology and clinical use of methotrexate N Engl J Med 309 1094-1104

[4] Callen JP(2003)Methotrexate as the “anchor drug” for the treatment of early rheumatoid arthritis Clin Exp Rheumatol 21 S179-S185

[5] Alarcón GS(2008)The safety and efficacy of adding etanercept to methotrexate or methotrexate to etanercept in moderately active rheumatoid arthritis patients previously treated with monotherapy Ann Rheum Dis 67 182-188

[6] Jolivet J(2012)Osteoporosis in children and young adults: a late effect after chemotherapy for bone sarcoma Clin Orthop Relat Res 470 2874-2885

[7] Cowan KH(1989)Antiproliferative effects of methotrexate on peripheral blood mononuclear cells Arthritis Rheum 32 378-385

[8] Curt GA(2010)Methotrexate–how does it really work? Nat Rev Rheumatol 6 175-178

[9] Clendeninn NJ(2005)Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines Inflamm Res 54 273-280

[10] Chabner BA(2011)Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK Arthritis Rheum 63 2606-2616

[1] Hanno R(1980)Methotrexate in psoriasis. A brief review of indications, usage, and complications of methotrexate therapy J Am Acad Dermatol 2 171-174

[2] Gruber GG(2000)Methotrexate use in rheumatoid arthritis. A clinician’s perspective Immunopharmacology 47 259-271

[3] Owen LG(1983)The pharmacology and clinical use of methotrexate N Engl J Med 309 1094-1104

[4] Callen JP(2003)Methotrexate as the “anchor drug” for the treatment of early rheumatoid arthritis Clin Exp Rheumatol 21 S179-S185

[5] Alarcón GS(2008)The safety and efficacy of adding etanercept to methotrexate or methotrexate to etanercept in moderately active rheumatoid arthritis patients previously treated with monotherapy Ann Rheum Dis 67 182-188

[6] Jolivet J(2012)Osteoporosis in children and young adults: a late effect after chemotherapy for bone sarcoma Clin Orthop Relat Res 470 2874-2885

[7] Cowan KH(1989)Antiproliferative effects of methotrexate on peripheral blood mononuclear cells Arthritis Rheum 32 378-385

[8] Curt GA(2010)Methotrexate–how does it really work? Nat Rev Rheumatol 6 175-178

[9] Clendeninn NJ(2005)Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines Inflamm Res 54 273-280

[10] Chabner BA(2011)Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK Arthritis Rheum 63 2606-2616