MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

被引：134

作者：

Ahmadi, Seyed Esmaeil ^{[1
]}

Rahimi, Samira ^{[1
]}

Zarandi, Bahman ^{[1
]}

Chegeni, Rouzbeh ^{[2
]}

Safa, Majid ^{[1
,3
]}

机构：

[1] Iran Univ Med Sci, Fac Allied Med, Dept Hematol & Blood Banking, Tehran, Iran

[2] Northern Illinois Univ, Med Lab Sci Program, Coll Hlth & Human Sci, De Kalb, IL 60115 USA

[3] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2021年 / 14卷 / 01期

关键词：

MYC; Oncogene; Regulation; Cell cycle; Apoptosis; DNA damage response; Prognostic importance; Therapeutic implications; Hematological malignancies; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; MANTLE CELL LYMPHOMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELL; DNA-DAMAGE RESPONSE; ACUTE PROMYELOCYTIC LEUKEMIA; ARF TUMOR-SUPPRESSOR; BOX-BINDING-PROTEIN; HEALTH-ORGANIZATION CLASSIFICATION;

D O I：

10.1186/s13045-021-01111-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

引用

页数：49

共 766 条

[1] Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest [J].