Community-acquired bacteremic Streptomyces atratus pneumonia in animmunocompetent adult: A case report

被引：6

作者：

Ariza-Prota M.A. ^{[1
]}

Pando-Sandoval A. ^{[1
]}

Fole-Vázquez D. ^{[1
]}

García-Clemente M. ^{[1
]}

Budiño T. ^{[1
]}

Casan P. ^{[1
]}

机构：

[1] Hospital Universitario Central de Asturias (HUCA), Instituto Nacional de Silicosis (INS), Área Del Pulmón, Facultad de Medicina, Universidad de Oviedo, Avenida Roma s/n, Oviedo, Asturias

来源：

Journal of Medical Case Reports | / 9卷 / 1期

关键词：

Bacteremia; Diagnosis; Infection; Pathogen; Pneumonia; Streptomyces;

D O I：

10.1186/s13256-015-0753-y

中图分类号：

学科分类号：

摘要：

Introduction: Streptomyces spp. are aerobic, Gram-positive bacteria of the order Actinomycetales, known for their ability to produce antimicrobial molecules such as streptomycin. Pneumonia due to Streptomyces is considered to be rare and limited to immunocompromised patients. Streptomyces spp. are only rarely associated with invasive systemic infections. To our knowledge, we report the first documented case of community-acquired Streptomyces atratus bacteremic pneumonia in an immunocompetent patient. Case presentation: We describe a case of Streptomyces atratus bacteremic pneumonia in an otherwise healthy, 77-year-old Spanish man. Streptomyces identified by 16S ribosomal RNA sequencing grew in multiple blood cultures and bronchoalveolar lavage cultures. The infection resolved completely after treatment with imipenem and amoxicillin/clavulanic acid for 2 months. Conclusions: The majority of cases reported in the literature make reference to the difficulty of determining the pathogenic role of Streptomyces spp. Usually considered a contaminant, the pathogenic role of Streptomyces spp. is easier to confirm when the species is isolated from a catheter tip and, in the case of blood cultures, in more than one sample with a high count of colonies. To our knowledge, we report the first documented case of Streptomyces atratus bacteremic pneumonia in an immunocompetent patient. As the experience is limited, further studies are needed to better understand the interpretation of the isolates of the genus Streptomyces; the predisposing factors for infection; and the course, treatment, and evolution of these infections. © 2015 Ariza-Prota et al.

引用

共 11 条

[1]

McNeil M.M., Brown J.M., The medically important aerobic Actinomycetes: Epidemiology and microbiology, Clin Microbiol Rev, 7, 3, pp. 357-417, (1994)

[2]

Patel J.B., Wallace R.J., Brown-Elliott B.A., Taylor T., Imperatrice C., Leonard D.G., Et al., Sequence-based identification of aerobic actinomycetes, J Clin Microbiol, 42, 6, pp. 2530-2540, (2004)

[3]

Kapadia M., Rolston K.V., Han X.Y., Invasive Streptomyces infections: Six cases and literature review, Am J Clin Pathol, 127, 4, pp. 619-624, (2007)

[4]

Rose Iii. C.E., Brown J.M., Fisher J.F., Brain abscess caused by Streptomyces infection following penetration trauma: Case report and results of susceptibility analysis of 92 isolates of Streptomyces species submitted to the CDC from 2000 to 2004, J Clin Microbiol, 46, 2, pp. 821-823, (2008)

[5]

Weinstein M.P., Murphy J.R., Reller L.B., Lichtenstein K.A., The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations with special reference to factors influencing prognosis, Rev Infect Dis, 5, 1, pp. 54-70, (1983)

[6]

Carey J., Motyl M., Perlman D.C., Catheter-related bacteremia due to Streptomyces in a patient receiving holistic infusions, Emerg Infect Dis., 7, pp. 1043-1045, (2001)

[7]

Ghanem G., Adachi J., Han X.Y., Raad I., Central venous catheter-related Streptomyces septic thrombosis, Infect Control Hosp Epidemiol., 28, pp. 599-601, (2007)

[8]

Nasher M.A., Hay J.R., Mahgoub E.S., Gumaa S.A., In vitro studies of antibiotic sensitivities of Streptomyces somaliensis - A cause of human actinomycetoma, Trans R Soc Trop Med Hyg., 83, pp. 265-268, (1989)

[9]

McNeil M.M., Brown J.M., Jarvis W.R., Ajello L., Comparison of species distribution and antimicrobial susceptibility of aerobic actinomycetes from clinical specimens, Rev Infect Dis., 12, pp. 778-783, (1990)

[10]

Kofteridis D.P., Maraki S., Scoulica E., Tsioutis C., Maltezakis G., Gikas A., Streptomyces pneumonia in an immunocompetent patient: A case report and literature review, Diagn Microbiol Infect Dis, 59, 4, pp. 459-462, (2007)

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