Excessive daytime sleepiness in obstructive sleep apnea patients after home CPAP treatment: A long-term outcome study

被引：0
作者：
Samson Yat-yuk Fong
Crover Kwok-Wah Ho
Albert Martin Li
Yun-Kwok Wing
机构：
[1] The Chinese University of Hong Kong,Sleep Assessment Unit, Department of Psychiatry, Shatin Hospital
[2] Chinese University of Hong Kong,Department of Paediatrics
[3] Princes of Wales Hospital,undefined
来源：
Sleep and Biological Rhythms | 2009年 / 7卷
关键词：
continuous positive airway pressure (CPAP) treatment; residual sleepiness; sleep apnea;
D O I：
暂无
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学科分类号：
摘要：
Previous studies have been inconclusive about the improvement in excessive daytime sleepiness (EDS) after continuous positive airway pressure (CPAP) treatment. One hundred and thirty-one obstructive sleep apnea patients, who were on regular home CPAP treatment, were investigated with an overnight polysomnography and daytime multiple sleep latency test (MSLT). Their Epworth Sleepiness Scale (ESS) scores and mean sleep latencies (MSL) before and after treatment were compared. With a mean duration of CPAP treatment for 3.4 ± 2.4 years, improvement in both ESS (12.8 to 9.95) and MSLT (7.32 to 8.92 min) were found (P < 0.001). Residual EDS was found in 38.5% (20 out of 52) and 66.2% (51 out of 77) of subjects, measured by ESS (≥14) and MSL (≤8 min), respectively. Higher body mass index was found in those subjects with persistently shortened post-CPAP MSL of ≤8 min. Our findings suggested that EDS was a reversible symptom in some but not all OSAS patients. Whilst residual EDS could partly be accounted for by underlying obesity, the persistence of a shortened MSLT and sleep-onset REM period could be the result of underlying genetic factors and/or scarring effect due to hypoxic related neuronal damages.
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页码：193 / 200
页数：7
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[1]  
Fong SYY(2005)Comparing MSLT and ESS in the measurement of excessive daytime sleepiness in obstructive sleep apnoea syndrome J. Psychosomatic Res. 58 55-60
[2]  
Ho CKW(1999)Hyper-somnolence in sleep-disordered breathing Am. J. Respir. Crit. Care Med. 159 1703-9
[3]  
Wing YK(2008)Subjective sleepiness among patients with obstructive sleep apnea-hypopnea syndrome who were treated with a continuous positive airway pressure device Sleep Biol. Rhythm. 6 155-62
[4]  
Punjabi NM(2006)Continuous positive airway pressure reduces daytime sleepiness in mild to moderate obstructive sleep apnoea: a meta-analysis Thorax 61 430-4
[5]  
O’Hearn DJ(1997)Effects of CPAP therapy on daytime function in patients with mild sleep apnoea/hypopnoea syndrome Thorax 52 114-19
[6]  
Neubauer DN(1999)Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome Am. J. Respir. Crit. Care Med. 159 461-7
[7]  
Kasai T(2001)Effectiveness of continuous positive airway pressure in mild sleep apneahypopnea syndrome Am. J. Respir. Crit. Care Med. 164 939-43
[8]  
Takaya J(2002)A randomized controlled trial of continuous positive airway pressure in mild obstructive sleep apnea Am. J. Respir. Crit. Care Med. 165 773-80
[9]  
Doh T(2004)Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea Am. J. Respir. Crit. Care Med. 170 656-64
[10]  
Marshall NS(2005)Randomized controlled crossover trial of humidified continuous positive airway pressure in mild obstructive sleep apnoea Thorax 60 427-32
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