Vitamin D deficiency, bone turnover markers and causative factors among adolescents: A cross-sectional study

被引：14

作者：

Larijani B. ^{[1
]}

Hossein-Nezhad A. ^{[1
]}

Feizabad E. ^{[1
]}

Maghbooli Z. ^{[1
]}

Adibi H. ^{[1
]}

Ramezani M. ^{[1
]}

Taheri E. ^{[1
]}

机构：

[1] Tehran University of Medical Sciences, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Shariati Hospital, North Kargar, Tehran

来源：

Journal of Diabetes & Metabolic Disorders | / 15卷 / 1期

关键词：

Adolescents; Bone turnover markers; Vitamin D deficiency;

D O I：

10.1186/s40200-016-0266-2

中图分类号：

学科分类号：

摘要：

Background: This cross-sectional population-based study was conducted to elucidate the prevalence of vitamin D deficiency, bone turnover marker's variation and its influencing factors among adolescents of Tehran. Methods: Totally 444 middle and high school (53.6 % in high school) students (both girls and boys) were recruited. A short food frequency questionnaire designed to estimate dietary calcium and vitamin D consumption. Serum levels of calcium, phosphorus, parathyroid hormone (PTH), bone specific alkaline phosphates, 25 (OH) vitamin D, osteocalcin, cross-linked C-telopeptide (CTX), total protein, albumin and creatinine were determined. Results: Vitamin D deficiency was prevalent in adolescents and only 22.4 % of students had normal serum vitamin D. Results revealed that vitamin D insufficiency reported in 34.2 % of students and vitamin D deficiency was in 43.3 % of them. Serum vitamin D, osteocalcin, CTX and bone specific alkaline phosphates were significantly higher in boys in all different ages. Serum levels of 25 (OH) vitamin D had positive influences on bone turnover markers and had negative correlation with PTH. Conclusions: Vitamin D deficiency and insufficiency is common among healthy adolescents of Tehran. There is a pressing need to improve vitamin D status among adolescents. Increasing vitamin D fortification of dairy products can be considered as a population-wide public health strategy in Iran. © 2016 The Author(s).

引用

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