Recovery from critical illness-induced organ failure: the role of autophagy

被引：0
作者：
Jan Gunst
机构：
[1] KU Leuven University and Hospital,Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine
来源：
Critical Care | / 21卷
关键词：
Critical illness; Sepsis; Autophagy; Nutrition; Insulin; Multiple organ dysfunction syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose.
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