One-pot synthesis and evaluation of anticancer activity of polyhydroquinoline derivatives catalyzed by [Msim]Cl

被引：0
作者：
S. C. Jadhvar
H. M. Kasraliker
S. V. Goswami
A. V. Chakrawar
S. R. Bhusare
机构：
[1] Dnyanopasak College,Department of Chemistry
来源：
Research on Chemical Intermediates | 2017年 / 43卷
关键词：
Anticancer activity; [Msim]Cl; Polyhydroquinolines; Salicylaldehyde; One-pot synthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A green protocol for an effective synthesis of bioactive polyhydroquinoline derivatives was developed via condensation of substituted salicylaldehyde, dimedone, ethyl acetoacetate and ammonium acetate catalyzed by 3-methyl-1-sulfonic acid imidazolium chloride ([Msim]Cl) in excellent yield. All synthesized derivatives were evaluated for inhibition of cancer cells. The initial assays reveals that some of the synthesized derivatives show significantly satisfactory inhibition activities against human breast cancer cells (MCF7) compared with the control (Adriamycin), which might be developed as novel lead scaffold for potential anticancer agents.
引用
收藏
页码：7211 / 7221
页数：10
相关论文
共 50 条
  • [31] One-pot Synthesis, Anticancer Evaluation, and Molecular Modelling Studies of New Quinazolin-4(1H)-one Derivatives
    Srinivas, A.
    Shree, A. Jaya
    Goud, S. S. Kumar
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 59 (09) : 1583 - 1590
  • [32] One-pot Synthesis, Anticancer Evaluation, and Molecular Modelling Studies of New Quinazolin-4(1H)-one Derivatives
    A. Srinivas
    A. Jaya Shree
    S. S. Kumar Goud
    Russian Journal of Organic Chemistry, 2023, 59 : 1583 - 1590
  • [33] New and efficient one-pot method for the synthesis of spiro [indoline-2,1′-isobenzofuran] derivatives and evaluation of their anticancer activity by in vitro and in silico studies
    Alborz, Maryam
    Mohammadizadeh, Mohammad Reza
    Mardaneh, Pegah
    Hassani, Bahareh
    Mohabbati, Maryam
    Firuzi, Omidreza
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1321
  • [34] One-pot sustainable synthesis of novel pyrido[2,3-d]pyrimidinones and their evaluation for antitubercular and anticancer activity
    Tabassum, Sumaiya
    Ramaraj, Sankar Ganesh
    Rajprasad, J.
    Sadaiyandi, Vivekananthan
    Kumar, Niraj
    Govindaraju, Santhosh
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2025, 1025
  • [35] Preparation of some novel imidazopyridine derivatives of indole as anticancer agents: one-pot multicomponent synthesis, biological evaluation and docking studies
    Zohreh Bakherad
    Maliheh Safavi
    Saghi Sepehri
    Afshin Fassihi
    Hojjat Sadeghi-Aliabadi
    Mohammad Bakherad
    Hossein Rastegar
    Bagher Larijani
    Lotfollah Saghaie
    Mohammad Mahdavi
    Research on Chemical Intermediates, 2019, 45 : 5261 - 5290
  • [36] Ceric Ammonium Nitrate (CAN) catalyzes the one-pot synthesis of polyhydroquinoline via the Hantzsch reaction
    Ko, Shengkai
    Yao, Ching-Fa
    TETRAHEDRON, 2006, 62 (31) : 7293 - 7299
  • [37] One-Pot Synthesis of Benzopinacolone Derivatives from Acetophenones
    Meira, Andreia Joice O.
    de Queiroz, Thiago B.
    Omori, Alvaro T.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2025, 36 (01)
  • [38] Preparation of some novel imidazopyridine derivatives of indole as anticancer agents: one-pot multicomponent synthesis, biological evaluation and docking studies
    Bakherad, Zohreh
    Safavi, Maliheh
    Sepehri, Saghi
    Fassihi, Afshin
    Sadeghi-Aliabadi, Hojjat
    Bakherad, Mohammad
    Rastegar, Hossein
    Larijani, Bagher
    Saghaie, Lotfollah
    Mahdavi, Mohammad
    RESEARCH ON CHEMICAL INTERMEDIATES, 2019, 45 (10) : 5261 - 5290
  • [39] One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by p-TSA
    Cinnathambi Subramani Maheswari
    Rathinam Ramesh
    Appaswami Lalitha
    Research on Chemical Intermediates, 2017, 43 : 4165 - 4173
  • [40] One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by p-TSA
    Maheswari, Cinnathambi Subramani
    Ramesh, Rathinam
    Lalitha, Appaswami
    RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (07) : 4165 - 4173
12345