One-pot synthesis and evaluation of anticancer activity of polyhydroquinoline derivatives catalyzed by [Msim]Cl

被引：0
|
作者：
S. C. Jadhvar
H. M. Kasraliker
S. V. Goswami
A. V. Chakrawar
S. R. Bhusare
机构：
[1] Dnyanopasak College,Department of Chemistry
来源：
Research on Chemical Intermediates | 2017年 / 43卷
关键词：
Anticancer activity; [Msim]Cl; Polyhydroquinolines; Salicylaldehyde; One-pot synthesis;
D O I：
暂无
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学科分类号：
摘要：
A green protocol for an effective synthesis of bioactive polyhydroquinoline derivatives was developed via condensation of substituted salicylaldehyde, dimedone, ethyl acetoacetate and ammonium acetate catalyzed by 3-methyl-1-sulfonic acid imidazolium chloride ([Msim]Cl) in excellent yield. All synthesized derivatives were evaluated for inhibition of cancer cells. The initial assays reveals that some of the synthesized derivatives show significantly satisfactory inhibition activities against human breast cancer cells (MCF7) compared with the control (Adriamycin), which might be developed as novel lead scaffold for potential anticancer agents.
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页码：7211 / 7221
页数：10
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