Reduced melanoma tumor formation in mice immunized with DNA expressing the melanoma-specific antigen gp100/pmel17
被引:0
作者:
M Nawrath
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机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
M Nawrath
J Pavlovic
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h-index: 0
机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
J Pavlovic
R Dummet
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机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
R Dummet
J Schultz
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机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
J Schultz
B Strack
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机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
B Strack
J Heinrich
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机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
J Heinrich
K Moelling
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机构:Institute of Medical Virology of the University of Zurich,Department of Dermatology
K Moelling
机构:
[1] Institute of Medical Virology of the University of Zurich,Department of Dermatology
[2] University Hospital,undefined
来源:
Leukemia
|
1999年
/
13卷
关键词:
B16 melanoma;
naked DNA;
gp100;
pmel17;
GM-CSF;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Plasmid DNA encoding gene products of viruses or other pathogens has recently been applied by intramuscular injection as a novel type of vaccine. It can induce cytotoxic T cell response in small animals and protect against challenge with influenza A viruses. Combinations with cytokines or DNA-encoding cytokines have been applied in order to increase the efficiency of protection. A DNA vaccine has been analyzed here against malignant melanoma encoding gp100/pmel17, a melanoma-associated antigen. A small animal model was used by injection of B16 melanoma cells to syngeneic C57Bl/6 mice. DNA vaccination before tumor cell challenge leads to about 50% reduction of tumor size. The cytokine gene coding for GM-CSF did not increase the efficiency but also led to tumor size reduction when applied alone.