Reduced melanoma tumor formation in mice immunized with DNA expressing the melanoma-specific antigen gp100/pmel17

被引:0
作者
M Nawrath
J Pavlovic
R Dummet
J Schultz
B Strack
J Heinrich
K Moelling
机构
[1] Institute of Medical Virology of the University of Zurich,Department of Dermatology
[2] University Hospital,undefined
来源
Leukemia | 1999年 / 13卷
关键词
B16 melanoma; naked DNA; gp100; pmel17; GM-CSF;
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摘要
Plasmid DNA encoding gene products of viruses or other pathogens has recently been applied by intramuscular injection as a novel type of vaccine. It can induce cytotoxic T cell response in small animals and protect against challenge with influenza A viruses. Combinations with cytokines or DNA-encoding cytokines have been applied in order to increase the efficiency of protection. A DNA vaccine has been analyzed here against malignant melanoma encoding gp100/pmel17, a melanoma-associated antigen. A small animal model was used by injection of B16 melanoma cells to syngeneic C57Bl/6 mice. DNA vaccination before tumor cell challenge leads to about 50% reduction of tumor size. The cytokine gene coding for GM-CSF did not increase the efficiency but also led to tumor size reduction when applied alone.
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页码:S48 / S51
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