A review of the neuroprotective effects of andrographolide in Alzheimer's disease

被引：0
作者：
Zahra Abedi
Hamidon Basri
Zurina Hassan
Liyana Najwa Inche Mat
Huzwah Khaza’ai
Nur Afiqah Mohamad
机构：
[1] University Putra Malaysia,Department of Medicine, Faculty of Medicine and Health Science
[2] Universiti Sains Malaysia,Centre for Drug Research
来源：
Advances in Traditional Medicine | 2021年 / 21卷
关键词：
Andrographolide; Alzheimer’s disease; Neuroinflammation; Pro-inflammatory cytokines; Cognitive; Spatial memory;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alzheimer’s disease, characterized by amyloid beta peptides and neurofibrillary tangles, is the most prevalent cause of dementia. Nowadays, some novel medicines being developed have displayed more illustrious therapeutic efficacies in Alzheimer’s disease. Recent studies have found andrographolide exhibiting therapeutic efficacy in a variety of Alzheimer’s disease models. Andrographolide is a traditional herbal medicine compound extracted from Andrographis paniculata. Evidence has shown that andrographolide reduces amyloid beta aggregation and suppresses neuroinflammatory response and synaptic dysfunction by reversing the microglia-mediated production of pro-inflammatory cytokines as well as Alzheimer’s disease-associated reduction in synaptic proteins. In the present review, the pharmacological effects of andrographolide are summarized and its mechanism of action against Alzheimer’s disease is discussed to discover the possibilities of andrographolide for Alzheimer’s disease prevention and therapy.
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页码：253 / 266
页数：13
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