The Sigma-1 Receptor Ligand Chlorpromazine Attenuates Store-Dependent Ca2+ Entry in Peritoneal Macrophages

被引：0
|
作者：
Milenina L.S. [1 ]
Krutetskaya Z.I. [1 ]
Antonov V.G. [2 ]
Krutetskaya N.I. [1 ]
机构：
[1] St. Petersburg State University, St. Petersburg
[2] Kirov Military Medical Academy, St. Petersburg
来源：
Biophysics | 2021年 / 66卷 / 1期
关键词：
Keywords: sigma-1 receptors; macrophages; store-dependent Ca[!sup]2+[!/sup;
D O I：
10.1134/S0006350921010115
中图分类号：
学科分类号：
摘要：
Using Fura-2AM, a fluorescent Ca2+ indicator, we have shown for the first time that sigma-1 receptor antagonist - neuroleptic chlorpromazine - significantly inhibits the store-dependent Ca2+ entry induced by immunomodulators glutoxim as well as molixan and endoplasmic reticulum Са2+-ATPase inhi-bitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages. © 2021, Pleiades Publishing, Inc.
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页码：77 / 83
页数：6
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