Aberrant regional homogeneity of resting-state executive control, default mode, and salience networks in adult patients with moyamoya disease

被引:0
作者
Yu Lei
Jiabin Su
Hanqiang Jiang
Qihao Guo
Wei Ni
Heng Yang
Yuxiang Gu
Ying Mao
机构
[1] Huashan Hospital of Fudan University,Department of Neurosurgery
[2] Huashan Hospital of Fudan University,Department of Neurology
来源
Brain Imaging and Behavior | 2017年 / 11卷
关键词
Executive function; Functional magnetic resonance imaging; Moyamoya disease; Regional homogeneity;
D O I
暂无
中图分类号
学科分类号
摘要
Aberrant local connectivity within cerebral intrinsic connectivity networks (ICNs) at rest has not been reported in adult moyamoya disease (MMD). Our aim was to examine the regional homogeneity (ReHo) of executive control (ECN), default mode (DMN), and salience networks (SN) in patients with executive dysfunction to explore the underlying mechanism. Twenty-six adult patients with MMD and 24 normal control (NC) subjects were recruited. Executive function was evaluated by Trail Making Test Part B (TMT-B) and executive subtests of Memory and Executive Screening (MES-EX). Compared with NC, the case group exhibited ReHo decrease mainly in the frontal and parietal gyrus, and increase only in the left middle temporal gyrus. Subsequent ICNs analysis indicated that compared with NC, patients with MMD exhibited significantly decreased ReHo in the dorsolateral prefrontal cortex (DLPFC) and inferior parietal gyrus (IPG) of left ECN; the IPG, superior frontal gyrus, and DLPFC of the right ECN; the right precuneus, left medial superior frontal gyrus, and right medial orbitofrontal gyrus of the DMN; as well as the left middle frontal gyrus and right supplemental motor area of SN. When referring to the Suzuki’s 6-stage classification, a trend of ReHo decrease with disease severity was observed in all of the ICNs examined, but only bilateral ECNs reached statistical significance. Finally, only bilateral ECNs exhibited a significant correlation of averaged ReHo values with executive performance. Our results provide new insight into the pathophysiology of adult MMD.
引用
收藏
页码:176 / 184
页数:8
相关论文
共 50 条
[41]   Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis [J].
Han, Weijian ;
Su, Yousong ;
Wang, Xiangwen ;
Yang, Tao ;
Zhao, Guoqing ;
Mao, Ruizhi ;
Zhu, Na ;
Zhou, Rubai ;
Wang, Xing ;
Wang, Yun ;
Peng, Daihui ;
Wang, Zuowei ;
Fang, Yiru ;
Chen, Jun ;
Sun, Ping .
JOURNAL OF AFFECTIVE DISORDERS, 2025, 379 :313-322
[42]   Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment [J].
Kocher, Martin ;
Jockwitz, Christiane ;
Caspers, Svenja ;
Schreiber, Jan ;
Farrher, Ezequiel ;
Stoffels, Gabriele ;
Filss, Christian ;
Lohmann, Philipp ;
Tscherpel, Caroline ;
Ruge, Maximilian, I ;
Fink, Gereon R. ;
Shah, Nadim J. ;
Galldiks, Norbert ;
Langen, Karl-Josef .
NEUROIMAGE-CLINICAL, 2020, 27
[43]   Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study [J].
Jiang, Wen-tao ;
Liu, Xia ;
Xu, Zi-yun ;
Zhou, Zhi-feng ;
Tie, Chang-jun ;
Liu, Xiao-ying ;
Yang, Ji-hui ;
Li, Hai ;
Lai, Wen-tao .
BRAIN AND BEHAVIOR, 2023, 13 (12)
[44]   Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease [J].
Shihao He ;
Ziqi Liu ;
Yanchang Wei ;
Ran Duan ;
Zongsheng Xu ;
Cai Zhang ;
Li Yuan ;
Tian Li ;
Ning Ma ;
Xin Lou ;
Xiaoyuan Liu ;
Rong Wang .
BMC Neuroscience, 22
[45]   Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease [J].
He, Shihao ;
Liu, Ziqi ;
Wei, Yanchang ;
Duan, Ran ;
Xu, Zongsheng ;
Zhang, Cai ;
Yuan, Li ;
Li, Tian ;
Ma, Ning ;
Lou, Xin ;
Liu, Xiaoyuan ;
Wang, Rong .
BMC NEUROSCIENCE, 2021, 22 (01)
[46]   Donepezil's Effects on Brain Functions of Patients With Alzheimer Disease: A Regional Homogeneity Study Based on Resting-State Functional Magnetic Resonance Imaging [J].
Cheng, Jianan ;
Yang, Hua ;
Zhang, Jiangtao .
CLINICAL NEUROPHARMACOLOGY, 2019, 42 (02) :42-48
[47]   Altered dynamic intrinsic brain activity of the default mode network in Alzheimer's disease: A resting-state fMRI study [J].
Liao, Zhengluan ;
Sun, Wangdi ;
Liu, Xiaozheng ;
Guo, Zhongwei ;
Mao, Dewang ;
Yu, Enyan ;
Chen, Yan .
FRONTIERS IN HUMAN NEUROSCIENCE, 2022, 16
[48]   Altered regional homogeneity of spontaneous brain activity in patients with toothache: A resting-state functional magnetic resonance imaging study [J].
Yang, Jun ;
Shao, Yi ;
Li, Bin ;
Yu, Qiu-Yue ;
Ge, Qian-Min ;
Li, Biao ;
Pan, Yi-Cong ;
Liang, Rong-Bin ;
Wu, Shi-Nan ;
Li, Qiu-Yu ;
He, Yu-Lin .
FRONTIERS IN NEUROSCIENCE, 2022, 16
[49]   Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study [J].
Huang, Xin ;
Li, Hai-Jun ;
Ye, Lei ;
Zhang, Ying ;
Wei, Rong ;
Zhong, Yu-Lin ;
Peng, De-Chang ;
Shao, Yi .
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2016, 12 :1901-1906
[50]   Altered spontaneous brain activity in patients with asthma: a resting-state functional MRI study using regional homogeneity analysis [J].
Huang, Hui ;
Li, Si-Yu ;
Shi, Ling ;
Huang, Xin ;
Wang, Jun .
NEUROREPORT, 2021, 32 (18) :1403-1407