Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

被引：17

作者：

Li C.-B. ^{[1
]}

Wang C. ^{[1
,2
]}

Fan W.-W. ^{[1
,2
]}

Dong F.-W. ^{[1
,2
]}

Xu F.-Q. ^{[1
,2
]}

Wan Q.-L. ^{[1
]}

Luo H.-R. ^{[1
]}

Liu Y.-Q. ^{[1
]}

Hu J.-M. ^{[1
]}

Zhou J. ^{[1
]}

机构：

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming

[2] University of Chinese Academy of Sciences, Beijing

来源：

Natural Products and Bioprospecting | 2013年 / 3卷 / 2期

关键词：

bibenzyl; Dendrobium crepidatum; neurite outgrowth enhancing activity; Orchidaceae;

D O I：

10.1007/s13659-012-0103-3

中图分类号：

学科分类号：

摘要：

15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 µM. [Figure not available: see fulltext.]. © 2012, The Author(s).

引用

页码：70 / 73

页数：3

共 21 条

[1]

Dictionary of Chinese Medicines, pp. 586-590, (1986)

[2]

Chinese Pharmacopoeia, pp. 85-87, (2010)

[3]

19, pp. 109-110, (1999)

[4]

Elander M., Leander K., Rosenblom J., Ruusa E., Acta Chem. Scand., 27, pp. 1907-1913, (1973)

[5]

Hu J.M., Chen J.J., Yu H., Zhao Y.X., Zhou J., J. Asian Nat. Prod. Res., 10, pp. 647-651, (2008)

[6]

Hu J.M., Chen J.J., Yu H., Zhao Y.X., Zhou J., Planta Med., 74, pp. 535-539, (2008)

[7]

Hu J.M., Zhao Y.X., Miao Z.H., Zhou J., Bull. Korean Chem. Soc., 30, pp. 2098-2100, (2009)

[8]

Hu J.M., Fan W.W., Dong F.W., Miao Z.H., Zhou J., Chin. J. Chem., 30, pp. 1327-1330, (2012)

[9]

Wang C.Z., Jia Z.J., Shen X.M., India J. Chem., 36, pp. 150-153, (1997)

[10]

Letcher R.M., Nhamo L.R.M., J. Chem. Soc., Perkin Trans I, 23, pp. 2941-2946, (1972)

← 1 2 3 →