Long-Term Changes in Spontaneous Behavior and c-Fos Expression in the Brain in Mice in the Resting State in a Model of Post-Traumatic Stress Disorder

被引：1

作者：

Toropova K.A. ^{[1
,2
,3
,4
]}

Ivashkina O.I. ^{[1
,2
,4
]}

Ivanova A.A. ^{[1
]}

Konovalova E.V. ^{[4
]}

Dolgov O.N. ^{[1
]}

Anokhin K.V. ^{[2
,3
,4
]}

机构：

[1] National Research Center Kurchatov Institute, Moscow

[2] Institute for Advanced Brain Research, Lomonosov Moscow State University, Moscow

[3] Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow

[4] Anokhin Research Institute of Normal Physiology, Moscow

来源：

Neuroscience and Behavioral Physiology | 2021年 / 51卷 / 5期

关键词：

amygdala; animal models; anxiety; associative areas of the cortex; c-Fos; post-traumatic stress disorder; resting state; sensitization; spontaneous behavior; traumatic experience;

D O I：

10.1007/s11055-021-01116-z

中图分类号：

学科分类号：

摘要：

The development of post-traumatic stress disorder (PTSD) in humans includes a number of symptoms, the main being intrusive memories of the trauma, psychological and physiological hyperreactivity on reminding of the trauma, and increased anxiety, and specific memory impairments. Current models of PTSD in animals address the last three of these symptoms but do not provide for study of spontaneously arising intrusive memories or their neural basis. The study reported here uses contemporary methods for continuous monitoring of behavior and showed that the development of PTSD in mice was accompanied by specific changes in spontaneous behavior in their home cages. These changes were long-lasting and included decreased exploratory activity and elevated anxiety. Thus, we showed that mice display the behavioral manifestations of human-typical spontaneously arising PTSD symptoms which in humans are associated with intrusive memories of the trauma. In addition, studies of neuron electrical activity-dependent expression of transcription factor c-Fos showed that the brains of mice with PTSD, even when the animal was at rest and not receiving external reminders of the trauma experienced, showed increased spontaneous activity in the cingulate and retrosplenial cortex, amygdala, thalamus, and periaqueductal gray matter. Thus, our studies demonstrated the spontaneous manifestations of PTSD in a mouse model at both the behavioral and neural levels. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

引用

页码：629 / 638

页数：9

共 48 条

[11]

Falconer E., Allen A., Felmingham K.L., Et al., Inhibitory neural activity predicts response to cognitive-behavioral therapy for posttraumatic stress disorder, J. Clin. Psychiatry, 74, 9, pp. 895-901, (2013)

[12]

Fenster R.J., Lebois L.A.M., Ressler K.J., Suh J., Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man, Nat. Rev. Neurosci., 19, 9, pp. 535-551, (2018)

[13]

Franklin K.B.J., Paxinos G., The Mouse Brain in Stereotaxic Coordinates, (2007)

[14]

Gvozdanovic G.A., Stampfli P., Seifritz E., Rasch B., Neural correlates of experimental trauma memory retrieval, Hum. Brain Mapp., 38, 7, pp. 3592-3602, (2017)

[15]

Harricharan S., Rabellino D., Frewen P.A., Et al., fMRI functional connectivity of the periaqueductal gray in PTSD and its dissociative subtype, Brain Behav., 6, 12, (2016)

[16]

Holter S.M., Einicke J., Sperling B., Et al., Tests for anxiety-related behavior in mice, Curr. Protoc. Mouse Biol., 5, 4, pp. 291-309, (2015)

[17]

Hopper J.W., Frewen P.A., van der Kolk B.A., Lanius R.A., Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery, J. Trauma Stress, 20, 5, pp. 713-725, (2007)

[18]

Jeong H., Chung Y.A., Ma J., Et al., Diverging roles of the anterior insula in trauma-exposed individuals vulnerable or resilient to posttraumatic stress disorder, Sci. Rep., 9, 1, (2019)

[19]

Jud C., Schmutz I., Hampp G., Et al., A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions, Biol. Proced. Online, 7, pp. 101-116, (2005)

[20]

Kekelidze Z.I., Portnova A.A., Diagnostic criteria for post-traumatic stress disorder, Zh. Nevrol. Psikhiat., 109, pp. 4-7, (2009)

← 1 2 3 4 5 →