Oral mucosal melanoma treated with carbon ion radiotherapy: A case report

被引：0

作者：

Musha A. ^{[1
,2
]}

Saitoh J.-I. ^{[1
]}

Shirai K. ^{[1
]}

Yokoo S. ^{[2
]}

Ohno T. ^{[1
]}

Nakano T. ^{[1
]}

机构：

[1] Gunma University, Heavy Ion Medical Center, 3-39-22 Showa-machi, Maebashi, Gunma

[2] Department of Stomatology and Maxillofacial Surgery, Gunma University, Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma

来源：

Journal of Medical Case Reports | / 10卷 / 1期

基金：

日本学术振兴会;

关键词：

Carbon ion radiotherapy; Concomitant chemotherapy; Head and neck tumor; Oral mucosal melanoma;

D O I：

10.1186/s13256-016-1071-8

中图分类号：

学科分类号：

摘要：

Background: Oral mucosal melanoma is a rare disease with a relatively poor prognosis. Carbon ion radiotherapy has been shown to be effective against radiotherapy-resistant tumors owing to its excellent dose concentration and high biological effect. Case presentation: Our patient was a 66-year-old Japanese man with oral mucosal melanoma of his right maxillary gingiva (T4aN0M0). He received carbon ion radiotherapy at 57.6 Gy (relative biological effectiveness) in 16 fractions for 4 weeks. Concomitant chemotherapy (dacarbazine + nimustine + vincristine) was administered at the same time as carbon ion radiotherapy initiation. Two courses of adjuvant chemotherapy were given after carbon ion radiotherapy. Although he experienced grade 2 acute oral mucositis, his symptoms improved within a few weeks of undergoing carbon ion radiotherapy. He was alive at the time of reporting, 35 months after treatment, without any recurrence. Late toxicity has not been observed. Conclusions: Carbon ion radiotherapy for oral mucosal melanoma resulted in a good local effect. © 2016 The Author(s).

引用

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