The role of m6A methylation in osteosarcoma biological processes and its potential clinical value

被引：0
作者：
Yanjiao Wu
Zhiyun Wang
Jianlin Shen
Wei Yan
Shurong Xiang
Huan Liu
Wenhua Huang
机构：
[1] Southern Medical University (The First People’s Hospital of Shunde),Shunde Hospital
[2] Southern Medical University,Guangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences
[3] Southern Medical University,Guangdong Engineering Research Center for Translation of Medical 3D Printing Application
[4] Southern Medical University,Guangdong Innovation Platform for Translation of 3D Printing Application
[5] Affiliated Traditional Chinese Medicine Hospital,Department of Orthopaedics
[6] Southwest Medical University,The Precision Medicine Institute, The Third Affiliated Hospital
[7] Southern Medical University,Department of Anatomy
[8] Hebei Medical University,undefined
来源：
Human Genomics | / 16卷
关键词：
m6A modification; Osteosarcoma; Epigenetics; Writers; Erasers; Readers;
D O I：
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摘要：
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and young adults and has a poor prognosis. Recent developments in the field of high-throughput sequencing technology, particularly in methylated RNA immunoprecipitation sequencing (MeRIP-seq), have led to renewed interest in RNA methylation. Among the various RNA modifications, N6-methyladenosine (m6A) modifications are the most common. Emerging evidence suggests that m6A methylation can affect the complexity of cancer progression by regulating biological functions related to cancer. In this review, we will shed light on recent findings regarding the biological function of m6A methylation in OS and discuss future research directions and potential clinical applications of RNA methyltransferases in OS.
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