Effect of DNA Methylation on the Velocity of DNA Translocation through a Nanochannel

被引：0

作者：

Xiaoyin Sun

Takao Yasui

Takeshi Yanagida

Noritada Kaji

Sakon Rahong

Masaki Kanai

Kazuki Nagashima

Tomoji Kawai

Yoshinobu Baba

机构：

[1] Nagoya University,Department of Applied Chemistry, Graduate School of Engineering

[2] Nagoya University,ImPACT Research Center for Advanced Nanobiodevices

[3] Japan Science and Technology Agency (JST),undefined

[4] PRESTO,undefined

[5] Institute of Materials Chemistry and Engineering,undefined

[6] Kyushu University,undefined

[7] Institute of Scientific and Industrial Research,undefined

[8] Osaka University,undefined

[9] Health Research Institute,undefined

[10] National Institute of Advanced Industrial Science and Technology (AIST),undefined

来源：

Analytical Sciences | 2017年 / 33卷

关键词：

DNA methylation; single DNA molecule; DNA translocation velocity; nanochannel;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Here, we report the effect of DNA methylation on the velocity of DNA translocation through a nanochannel, as determined by measuring differences in translocation velocities between methylated and non-methylated DNA molecules. We found that the velocity of translocation of methylated DNA was faster than that of non-methylated DNA, which we attributed to variation in the coefficients of diffusion and friction with the nanochannel wall, due to the increased molecular weight and stiffness, respectively, of methylated DNA.

引用

页码：727 / 730

页数：3

共 65 条

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