Spotlight on Peginterferon-α-2a (40KD) in Chronic Hepatitis C

被引：0
作者：
Caroline M. Perry
Blair Jarvis
机构：
[1] Adis International Limited,
[2] 41 Centorian Drive,undefined
来源：
BioDrugs | 2002年 / 16卷
关键词：
Chronic Hepatitis; Sustained Virological Response; Virological Response; Fatigue Severity Scale; Histological Improvement;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peginterferon-α-2a (40KD) is a new ‘pegylated’ subcutaneous formulation of interferon-α-2a that has been developed to improve on the pharmacokinetic profile and therapeutic efficacy of interferon-α-2a. Peginterferon-α-2a (40KD) is produced by the covalent attachment of recombinant interferon-α-2a to a branched mobile 40KD polyethylene glycol moiety, which shields the interferon-α-2a molecule from enzymatic degradation, reduces systemic clearance and enables once-weekly administration.
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页码：213 / 217
页数：4
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