The heads of the measles virus attachment protein move to transmit the fusion-triggering signal

被引：0
作者：
Chanakha K Navaratnarajah
Numan Oezguen
Levi Rupp
Leah Kay
Vincent H J Leonard
Werner Braun
Roberto Cattaneo
机构：
[1] Mayo Clinic,Department of Molecular Medicine
[2] Virology and Gene Therapy Track,Department of Biochemistry and Molecular Biology
[3] Mayo Graduate School,undefined
[4] University of Texas Medical Branch,undefined
[5] Sealy Center for Structural Biology and Molecular Biophysics,undefined
[6] University of Texas Medical Branch,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
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摘要：
Binding of measles virus hemagglutinin (MVH) to its cellular receptors triggers the activation of the fusion protein. The conformational changes of MVH upon receptor binding are now examined by locking the dimers using disulfide bonds, or by pulling on appropriately positioned hexahistidine tags. The results indicate that the dimer interface is pulled apart after receptor binding by twisting of the MVH heads.
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页码：128 / 134
页数：6
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