Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s disease

被引:0
作者
Huimin Cai
Yana Pang
Ziye Ren
Xiaofeng Fu
Longfei Jia
机构
[1] Capital Medical University,Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital
[2] National Clinical Research Center for Geriatric Diseases,Center of Alzheimer’s Disease, Beijing Institute of Brain Disorders
[3] Capital Medical University,undefined
来源
BMC Medicine | / 22卷
关键词
Alzheimer’s disease; Synaptic dysfunction; Growth-associated protein 43; Synaptosome-associated protein 25; Extracellular vesicles; Messenger RNAs;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 427 条
[1]  
Masters CL(2015)Alzheimer’s disease Nat Rev Dis Primers 1 15056-491
[2]  
Bateman R(2018)The cost of Alzheimer’s disease in China and re-estimation of costs worldwide Alzheimers Dement 14 483-1037
[3]  
Blennow K(2023)Amyloid-β-targeted therapies for Alzheimer’s disease: currently and in the future Ageing Neurodegener Dis 3 13-179
[4]  
Rowe CC(2022)A critical appraisal of tau-targeting therapies for primary and secondary tauopathies Alzheimers Dement 18 1008-a006189
[5]  
Sperling RA(2009)Synaptic degeneration in Alzheimer’s disease Acta Neuropathol (Berl) 118 167-28595
[6]  
Cummings JL(2011)Neuropathological alterations in Alzheimer disease Cold Spring Harb Perspect Med 1 a006189-199
[7]  
Jia J(2015)Thematic minireview series: molecular mechanisms of synaptic plasticity J Biol Chem 290 28594-1508
[8]  
Wei C(1993)Synapse loss in the temporal lobe in Alzheimer’s disease Ann Neurol 33 190-580
[9]  
Chen S(2007)Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment Neurology. 68 1501-618
[10]  
Li F(1991)Physical basis of cognitive alterations in Alzheimer’s disease: Synapse loss is the major correlate of cognitive impairment Ann Neurol 30 572-559