What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy

被引：54

作者：

Toramatsu, Chie ^{[1
]}

Katoh, Norio ^{[2
]}

Shimizu, Shinichi ^{[2
]}

Nihongi, Hideaki ^{[1
]}

Matsuura, Taeko ^{[1
]}

Takao, Seishin ^{[1
]}

Miyamoto, Naoki ^{[1
]}

Suzuki, Ryusuke ^{[1
]}

Sutherland, Kenneth ^{[1
]}

Kinoshita, Rumiko ^{[2
]}

Onimaru, Rikiya ^{[2
]}

Ishikawa, Masayori ^{[1
]}

Umegaki, Kikuo ^{[1
]}

Shirato, Hiroki ^{[2
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Med Phys, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Radiat Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

RADIATION ONCOLOGY | 2013年 / 8卷

基金：

日本学术振兴会;

关键词：

Spot-scanning proton therapy; Intensity-modulated radiation therapy; Hepatocellular carcinoma; Radiation induced liver disease; COMPLICATION PROBABILITY; NORMAL TISSUE; BEAM THERAPY; VOLUME; NTCP; OPTIMIZATION; IMPACT;

D O I：

10.1186/1748-717X-8-48

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD). Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm(3). Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model. Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT. Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm.

引用

页数：8

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