From checkpoint to checkpoint: DNA damage ATR/Chk1 checkpoint signalling elicits PD-L1 immune checkpoint activation

被引：0
作者：
Kent W. Mouw
Panagiotis A. Konstantinopoulos
机构：
[1] Harvard Medical School,Department of Radiation Oncology, Dana
[2] Harvard Medical School,Farber Cancer Institute/Brigham & Women’s Hospital
来源：
British Journal of Cancer | 2018年 / 118卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Multiple clinical studies have revealed a link between genomic instability and response to anti-PD-1/PD-L1 therapy in cancer management. A recent study has revealed an important role for the ATR/Chk1 DNA damage checkpoint in regulating PD-L1 expression, raising important clinical and translational questions for therapy selection and study design.
引用
收藏
页码：933 / 935
页数：2
相关论文
共 30 条
[1]  
Mouw KW(2017)DNA damage and repair biomarkers of immunotherapy response Cancer Discov. 7 675-693
[2]  
Sato H(2017)DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells Nat. Commun. 8 124-128
[3]  
Rizvi NA(2015)Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer Science 348 2509-2520
[4]  
Le DT(2015)PD-1 Blockade in tumors with mismatch-repair deficiency N. Engl. J. Med 372 13587-13598
[5]  
Strickland KC(2016)Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer Oncotarget 7 2206-2211
[6]  
Bouffet E(2016)Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency J. Clin. Oncol. 34 1319-1323
[7]  
Howitt BE(2015)Association of polymerase e-mutated and microsatellite-instable endometrial cancers with neoantigen load, number of tumor-infiltrating lymphocytes, and expression of PD-1 and PD-L1 JAMA Oncol. 1 130-134
[8]  
Mouw KW(2014)Crosstalk between the nucleotide excision repair and Fanconi anemia/BRCA pathways DNA Repair 19 1137-1154
[9]  
D’Andrea AD(2015)Homologous recombination deficiency: exploiting the fundamental vulnerability of ovarian cancer Cancer Discov. 5 243-254
[10]  
Konstantinopoulos PA(2010)53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks Cell 141 541-544
123