Age-related peculiarities of contractile activity of rat myocardium during blockade of hyperpolarization-activated currents

被引：0
作者：
T. L. Zefirov
A. E. Gibina
A. M. Sergejeva
N. I. Ziyatdinova
A. L. Zefirov
机构：
[1] Tatar State Humanitarian-Pedagogical University,Department of Anatomy, Physiology, and Human Health Protection
[2] Kazan State Medical University,Department of Normal Physiology
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 144卷
关键词：
heart; inotropy; hyperpolarization-activated currents; ontogeny; rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Contractile activity of atrial and ventricular myocardial strips isolated from rats of various age was examined under conditions of blockade of non-selective hyperpolarization-activated cation currents. Addition of ZD7288, a blocker of non-selective hyperpolarization-activated cation currents, to the perfusion solution increased the contraction force of atrial and ventricular strips in 1-, 8-, and 20-week rats, but produced an opposite effect on contractile activity of atrial and ventricular strips in 3-week rats.
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页码：273 / 275
页数：2
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