The diversity and breadth of cancer cell fatty acid metabolism

被引：0
作者：
Shilpa R. Nagarajan
Lisa M. Butler
Andrew J. Hoy
机构：
[1] The University of Sydney,Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health
[2] University of Oxford,Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine
[3] Churchill Hospital,Adelaide Medical School and Freemasons Foundation Centre for Men’s Health
[4] University of Adelaide,undefined
[5] South Australian Health and Medical Research Institute,undefined
来源：
Cancer & Metabolism | / 9卷
关键词：
Fatty acid; Lipid; Cellular membrane; De novo synthesis; Lipid droplets; Mitochondria; Peroxisome; Oxidation;
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摘要：
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, including growth factor and nutrient availability. Alongside glucose and amino acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.
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[41]  
Lee CH(2019)Lipid metabolism in cancer cells under metabolic stress Br J Cancer 120 1090-2301
[42]  
Creighton CJ(2018)Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress Biochim Biophys Acta Mol Cell Biol Lipids 1863 247-45
[43]  
Brannon AR(2016)Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism Elife 5 e10250-85
[44]  
Luna A(2014)Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth Semin Cancer Biol 25 47-2115
[45]  
Garg G(2013)Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids Proc Natl Acad Sci U S A 110 8882-20 e5
[46]  
Yilmaz A(2017)From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake Biochimie 136 21-4908
[47]  
Kumar P(2018)The enigmatic membrane fatty acid transporter CD36: new insights into fatty acid binding and their effects on uptake of oxidized LDL Prostaglandins Leukot Essent Fatty Acids 138 64-1025
[48]  
Turkoglu O(1995)Mechanism of activation and functional significance of the lipolysis-stimulated receptor. Evidence for a role as chylomicron remnant receptor Biochemistry 34 10421-1727
[49]  
Mutch DG(2018)The role of low-density lipoprotein receptor-related protein 1 in lipid metabolism, glucose homeostasis and inflammation Int J Mol Sci 19 1780-4840
[50]  
Powell MA(2018)SR-B1: A unique multifunctional receptor for cholesterol influx and efflux Annu Rev Physiol 80 95-218
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