Managing the local complications of locally advanced prostate cancer

被引：22
作者：
Anast J.W. [1 ]
Andriole G.L. [1 ]
Grubb III R.L. [1 ]
机构：
[1] Division of Urologic Surgery, Washington University School of Medicine, Campus Box 8242, St. Louis, MO 63110
来源：
Current Urology Reports | 2007年 / 8卷 / 3期
关键词：
Prostate Cancer; Urinary Diversion; Bladder Outlet Obstruction; Advanced Prostate Cancer; Ureteral Obstruction;
D O I：
10.1007/s11934-007-0008-6
中图分类号：
学科分类号：
摘要：
Complications of locally advanced prostate cancer are often overlooked in the overall treatment of prostate cancer, can have significant morbidity, and can provide a challenge for the treating urologist. Despite advances in early detection and treatment of prostate cancer, as many as 10% of patients present with or develop symptomatic locally advanced prostate cancer. Prostate cancer locally invading the urethra can be effectively managed with transurethral resection or ablation procedures or urethral stenting. Obstruction of one or both ureters is managed with either ureteral stenting or nephrostomy drainage. Bulky pelvic recurrence resulting in significant hematuria, rectal involvement, or severe pelvic pain can be difficult to manage, with some advocating cystoprostatectomy or pelvic exenteration to provide palliation. Surgical intervention for locally advanced prostate cancer can provide significant improvement in quality of life and should not be restricted to patients who have curable disease. Copyright © 2007 by Current Medicine Group LLC.
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页码：211 / 216
页数：5
相关论文
共 23 条
  • [1] Fowler Jr J.E., Bigler S.A., White P.C., Et al., Hormone therapy for locally advanced prostate cancer, J Urol, 168, pp. 546-549, (2002)
  • [2] Leibovici D., Lee A.K., Cheung R.M., Et al., Symptomatic local recurrence of prostate carcinoma after radiation therapy, Cancer, 103, pp. 2060-2066, (2005)
  • [3] Oefelein M.G., Prognostic significance of obstructive uropathy in advanced prostate cancer, Urology, 63, pp. 1117-1121, (2004)
  • [4] Fleischmann J.D., Catalona W.J., Endocrine therapy for bladder outlet obstruction from carcinoma of the prostate, J Urol, 134, pp. 498-500, (1985)
  • [5] Mazur A.W., Thompson I.M., Efficacy and morbidity of "channel" TURP, Urology, 38, pp. 526-528, (1991)
  • [6] Forman J.D., Order S.E., Zinreich E.S., Et al., The correlation of pretreatment transurethral resection of prostatic cancer with tumor dissemination and disease-free survival: A univariate and multivariate analysis, Cancer, 58, pp. 1770-1778, (1986)
  • [7] Engelhardt P.F., Riedl C.R., Re: Palliative transurethral prostate resection for bladder outlet obstruction in patients with locally advanced prostate cancer, J Urol, 173, pp. 324-325, (2005)
  • [8] Levine E.S., Cisek V.J., Mulvihill M.N., Et al., Role of transurethral resection in dissemination of cancer of prostate, Urology, 28, pp. 179-183, (1986)
  • [9] Crain D.S., Amling C.L., Kane C.J., Palliative transurethral prostate resection for bladder outlet obstruction in patients with locally advanced prostate cancer, J Urol, 171, pp. 668-671, (2004)
  • [10] Marszalek M., Ponholzer A., Rauchenwald M., Et al., Palliative transurethral resection of the prostate: Functional outcome and impact on survival, BJU Int, 99, pp. 56-59, (2006)
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