Effect of lipid on physicochemical properties of solid lipid nanoparticle of paclitaxel

被引:13
作者
Baek J.-S. [1 ]
Shin S.-C. [2 ]
Cho C.-W. [1 ]
机构
[1] College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, 305-764, 220 Gungdong, Yuseonggu
[2] College of Pharmacy, Chonnam National University, Gwangju
基金
新加坡国家研究基金会;
关键词
Behenic acid; Myristic acid; Paclitaxel; Palmitic acid; Solid lipid nanoparticle; Stearic acid;
D O I
10.1007/s40005-012-0038-z
中图分类号
学科分类号
摘要
The aim of this study was to compare physicochemical properties of solid lipid nanoparticles (SLN) made from different lipids. To make small, stable, uniform and highly encapsulated SLNs, many factors such as the components (lipid, stabilizer) and preparation condition (sonication time, power) can be considered. Out of those, we selected solid lipid as lipid matrix to investigate an effect on SLNs. The SLNs were characterized by particle size, zeta potential, solubility and in vitro release study. In this study, SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, M-SLN showed biggest particle size (412.5 ± 29.4 nm) and highest encapsulation efficiency (61.2 ± 4.8 %). And, B-SLN showed highest cumulative drug percentage (85.0 ± 1.7 %, 24 h) in release study. These results suggest that lipids type affect physicochemical properties and release profile of SLN. © 2012 The Korean Society of Pharmaceutical Sciences and Technology.
引用
收藏
页码:279 / 283
页数:4
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