Advances in intranasal application of stem cells in the treatment of central nervous system diseases

被引：0
作者：
Yu-Ting Zhang
Kai-Jie He
Jin-Bao Zhang
Quan-Hong Ma
Fen Wang
Chun-Feng Liu
机构：
[1] The Second Affiliated Hospital of Soochow University,Department of Neurology
[2] Soochow University,Institute of Neuroscience
来源：
Stem Cell Research & Therapy | / 12卷
关键词：
Intranasal application; Central nervous system; Stem cells;
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摘要：
Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders, especially in a noninvasive way. It has been shown that small molecular substances, macromolecular proteins, and even stem cells can bypass the BBB and reach the brain parenchyma following intranasal administration. Here, we review the possible brain-entry routes of transnasal treatment, the cell types, and diseases involved in intranasal stem cell therapy, and discuss its advantages and disadvantages in the treatment of central nervous system diseases, to provide a reference for the application of intranasal stem cell therapy.
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