Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

[1] Irby RB(1999)Activating SRC mutation in a subset of advanced human colon cancers Nat Genet 21 187-190

[2] Mao W(2014)C-Src drives intestinal regeneration and transformation EMBO J 33 1474-1491

[3] Coppola D(1989)Activity of pp60c-src protein kinase in human breast cancer Mt Sinai J Med 56 83-85

[4] Kang J(2000)Role of Src expression and activation in human cancer Oncogene 19 5636-5642

[5] Loubeau JM(2005)Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells Cancer Res 65 5535-5543

[6] Trudeau W(2011)Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling Sci Signal 4 ra18-7271

[7] Karl R(1997)The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src EMBO J 16 7261-775

[8] Fujita DJ(1997)The 2.35 a crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J Mol Biol 274 757-638

[9] Jove R(1999)Crystal structures of c-Src reveal features of its autoinhibitory mechanism Mol Cell 3 629-602

[10] Yeatman TJ(1997)Three-dimensional structure of the tyrosine kinase c-Src Nature 385 595-609

[1] Irby RB(1999)Activating SRC mutation in a subset of advanced human colon cancers Nat Genet 21 187-190

[2] Mao W(2014)C-Src drives intestinal regeneration and transformation EMBO J 33 1474-1491

[3] Coppola D(1989)Activity of pp60c-src protein kinase in human breast cancer Mt Sinai J Med 56 83-85

[4] Kang J(2000)Role of Src expression and activation in human cancer Oncogene 19 5636-5642

[5] Loubeau JM(2005)Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells Cancer Res 65 5535-5543

[6] Trudeau W(2011)Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling Sci Signal 4 ra18-7271

[7] Karl R(1997)The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src EMBO J 16 7261-775

[8] Fujita DJ(1997)The 2.35 a crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J Mol Biol 274 757-638

[9] Jove R(1999)Crystal structures of c-Src reveal features of its autoinhibitory mechanism Mol Cell 3 629-602

[10] Yeatman TJ(1997)Three-dimensional structure of the tyrosine kinase c-Src Nature 385 595-609