Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung

被引:0
|
作者
Ioannis Morianos
Aikaterini Tsitsopoulou
Konstantinos Potaris
Dimitrios Valakos
Ourania Fari
Giannis Vatsellas
Clementine Bostantzoglou
Andreas Photiades
Mina Gaga
Georgina Xanthou
Maria Semitekolou
机构
[1] Cellular Immunology Laboratory,Department of Thoracic Surgery
[2] Biomedical Research Foundation of the Academy of Athens (BRFAA),Present address: Department of Medicine I, Comprehensive Cancer Center, Institute of Cancer Research
[3] Athens Chest Hospital ‘Sotiria’,Intensive Care Unit
[4] Molecular Biology Laboratory,7th Respiratory Medicine Department and Asthma Center
[5] BRFAA,undefined
[6] Medical University of Vienna,undefined
[7] Greek Genome Center,undefined
[8] BRFAA,undefined
[9] Athens Chest Hospital ‘Sotiria’,undefined
[10] Athens Chest Hospital ‘Sotiria’,undefined
来源
Journal of Experimental & Clinical Cancer Research | / 40卷
关键词
Activin-A; Anti-tumor immunity; CD4; T cells; Non-small cell lung cancer; T cell exhaustion; Immune regulation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung
    Morianos, Ioannis
    Tsitsopoulou, Aikaterini
    Potaris, Konstantinos
    Valakos, Dimitrios
    Fari, Ourania
    Vatsellas, Giannis
    Bostantzoglou, Clementine
    Photiades, Andreas
    Gaga, Mina
    Xanthou, Georgina
    Semitekolou, Maria
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021, 40 (01)
  • [2] Apolipoprotein E deficiency enhances the anti-tumor immunity via repressing T cell exhaustion
    Zhao, Bian
    Wang, Wenbao
    Chen, Zhijun
    Jin, Shaoju
    ALL LIFE, 2021, 14 (01) : 1054 - 1062
  • [3] CD4+ cytotoxic T cells: an emerging effector arm of anti-tumor immunity
    Jeong, Seongmin
    Jang, Nawon
    Kim, Minchae
    Choi, Il-Kyu
    BMB REPORTS, 2023, 56 (03) : 140 - 144
  • [4] Induction of CD4+ and CD8+ anti-tumor effector T cell responses by bacteria mediated tumor therapy
    Stern, Christian
    Kasnitz, Nadine
    Kocijancic, Dino
    Trittel, Stephanie
    Riese, Peggy
    Guzman, Carlos A.
    Leschner, Sara
    Weiss, Siegfried
    INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (08) : 2019 - 2028
  • [5] CD4+ T cell apoptosis induced by anti-CD4 antibodies
    Zhihong Z.
    Yue Z.
    Huifen Z.
    Jing Y.
    Guanxin S.
    Current Medical Science, 2000, 20 (2) : 100 - 102
  • [6] CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis
    Zhang, Sheng
    Bernard, Dannie
    Khan, Waliul I.
    Kaplan, Mark H.
    Bramson, Jonathan L.
    Wan, Yonghong
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (05) : 1252 - 1259
  • [7] Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer
    Mo, Lijun
    Chen, Qianmei
    Zhang, Xinji
    Shi, Xiaojun
    Wei, Lili
    Zheng, Dianpeng
    Li, Hongwei
    Gao, Jimin
    Li, Jinlong
    Hu, Zhiming
    VACCINE, 2017, 35 (43) : 5932 - 5938
  • [8] Activin A promoted the anti-tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma
    Hu, Liangchang
    Zhao, Yu
    Zhang, Xuguang
    Ma, Chunhui
    CANCER MEDICINE, 2025, 14 (01):
  • [9] Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity
    Cho, John S.
    Hsu, JeVrey V.
    Morrison, Sherie L.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (07) : 1057 - 1069
  • [10] Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity
    Xuyu Gu
    Chanchan Gao
    Xiangyu Su
    Yaoyao Zhu
    Qiyu Fang
    Jia Yu
    Ziming Wang
    Deping Zhao
    Wentian Zhang
    Molecular Cancer, 24 (1)