TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas

被引:0
作者
Xiaoqin Yin
Bo Wang
Weidong Gan
Wenyuan Zhuang
Zou Xiang
Xiaodong Han
Dongmei Li
机构
[1] Nanjing University,Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School
[2] Nanjing University,Jiangsu Key Laboratory of Molecular Medicine
[3] Affiliated Drum Tower Hospital of Medical School of Nanjing University,Department of Urology
[4] The Hong Kong Polytechnic University,Department of Health Technology and Informatics, Faculty of Health and Social Sciences
来源
Journal of Experimental & Clinical Cancer Research | / 38卷
关键词
TFE3; mTOR; Subcellular localization; Nuclear retention; Lysosome; Transcription factor;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 41 条
  • [31] ALK rearrangement in TFE3-positive renal cell carcinoma: Alternative diagnostic option to exclude Xp11.2 translocation carcinoma
    Zhu, Yiqi
    Liu, Ning
    Guo, Wei
    Pu, Xiaohong
    Guo, Hongqian
    Gan, Weidong
    Li, Dongmei
    PATHOLOGY RESEARCH AND PRACTICE, 2020, 216 (12)
  • [32] Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
    Hu, Liang
    Li, Lina
    Li, Angcheng
    Tong, Jianyong
    OPEN MEDICINE, 2024, 19 (01):
  • [33] Xp11.2 translocation renal cell carcinoma with SFPQ/PSF-TFE3 fusion gene: A case report with unusual histopathologic findings
    Ishikawa, Noriyoshi
    Nagase, Mamiko
    Takami, Saki
    Nagano, Nahoko
    Araki, Asuka
    Iwahashi, Teruaki
    Yamauchi, Naotaka
    Yamasaki, Taku
    Shiina, Hiroaki
    Maruyama, Riruke
    PATHOLOGY RESEARCH AND PRACTICE, 2019, 215 (09)
  • [34] Adult-onset renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusion with smooth muscle stroma and abnormal vessels
    Kuroda, Naoto
    Tamura, Masato
    Tanaka, Yukichi
    Hes, Ondrej
    Michal, Michal
    Inoue, Kaori
    Ohara, Masahiko
    Mizuno, Keiko
    Lee, Gang-Hong
    PATHOLOGY INTERNATIONAL, 2009, 59 (07) : 486 - 491
  • [35] RBM10-TFE3 Renal Cell Carcinoma A Potential Diagnostic Pitfall Due to Cryptic Intrachromosomal Xp11.2 Inversion Resulting in False-negative TFE3 FISH
    Argani, Pedram
    Zhang, Lei
    Reuter, Victor E.
    Tickoo, Satish K.
    Antonescu, Cristina R.
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (05) : 655 - 662
  • [36] Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases
    Hodge, Jennelle C.
    Pearce, Kathryn E.
    Wang, Xiaoke
    Wiktor, Anne E.
    Oliveira, Andre M.
    Greipp, Patricia T.
    MODERN PATHOLOGY, 2014, 27 (01) : 113 - 127
  • [37] Renal Cell Carcinoma Associated With Transcription Factor E3 Expression and Xp11.2 Translocation Incidence, Characteristics, and Prognosis
    Klatte, Tobias
    Streubel, Berthold
    Wrba, Friedrich
    Remzi, Mesut
    Krammer, Barbara
    de Martino, Michela
    Waldert, Matthias
    Marberger, Michael
    Susani, Martin
    Haitel, Andrea
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2012, 137 (05) : 761 - 768
  • [38] Diagnosis of Xp11 translocation renal cell carcinomas in adult patients under 50 years: Interest and pitfalls of automated immunohistochemical detection of TFE3 protein
    Gaillot-Durand, L.
    Chevallier, M.
    Colombel, M.
    Couturier, J.
    Pierron, G.
    Scoazec, J. Y.
    Mege-Lechevallier, F.
    PATHOLOGY RESEARCH AND PRACTICE, 2013, 209 (02) : 83 - 89
  • [39] Newly Designed Break-Apart and ASPL-TFE3 Dual-Fusion FISH Assay Are Useful in Diagnosing Xp11.2 Translocation Renal Cell Carcinoma and ASPL-TFE3 Renal Cell Carcinoma A STARD-Compliant Article
    Chen, Xiancheng
    Yang, Yang
    Gan, Weidong
    Xu, Linfeng
    Ye, Qing
    Guo, Hongqian
    MEDICINE, 2015, 94 (19)
  • [40] Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network
    Malouf, G. G.
    Camparo, P.
    Oudard, S.
    Schleiermacher, G.
    Theodore, C.
    Rustine, A.
    Dutcher, J.
    Billemont, B.
    Rixe, O.
    Bompas, E.
    Guillot, A.
    Boccon-Gibod, L.
    Couturier, J.
    Molinie, V.
    Escudier, B.
    ANNALS OF ONCOLOGY, 2010, 21 (09) : 1834 - 1838