Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics

被引:0
作者
J. Martínez-Clemente
R. López-Arnau
M. Carbó
D. Pubill
J. Camarasa
E. Escubedo
机构
[1] University of Barcelona,Department of Pharmacology and Therapeutic Chemistry (Pharmacology Section) and Institute of Biomedicine (IBUB), Faculty of Pharmacy
[2] IMIM—Hospital del Mar Medical Research Institute,Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program
[3] Universitat Pompeu Fabra Barcelona,Department of Experimental and Health Sciences
来源
Psychopharmacology | 2013年 / 229卷
关键词
Mephedrone; Pharmacokinetics; Locomotor activity; PK/PD modeling; Rat;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:295 / 306
页数:11
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[1]  
Barrett PH(1998)SAAM II: Simulation, Analysis and Modeling Software for tracer and pharmacokinetics studies Metabolism 147 484-492
[2]  
Bell BM(2012)The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue Neuropsychopharmacology 37 1192-1203
[3]  
Cobelli C(2013)Psychoactive “bath salts”: not so soothing Eur J Pharmacol 698 1-5
[4]  
Golde H(2012)Linking the pharmacological content of ecstasy tablets to the subjective experiences of drug users Psychopharmacology (Berl) 220 751-762
[5]  
Schumitzky A(1996)Disposition of mehylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion Biochem Pharmacol 51 789-796
[6]  
Vicini P(1999)Inhibition of plasma membrane monoamine transporters by betaketoamphetamines Eur J Pharmacol 381 63-69
[7]  
Foster DM(2006)Pharmacokinetic–pharmacodynamic modeling: history and perspectives J Pharmacokinet Pharmacodyn 33 227-279
[8]  
Baumann MH(2010)Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin J Anal Toxicol 34 162-168
[9]  
Ayestas MA(2009)Sprague–Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) Toxicol Appl Pharmacol 241 339-347
[10]  
Partilla JS(2011)4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse J Pharmacol Exp Ther 339 530-536