Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

[1] Schwartzbaum JA(2006)Epidemiology and molecular pathology of glioma Nat Clin Pract Neurol 2 494-503

[2] Fisher JL(2015)Treatment of obesity with celastrol Cell. 161 999-1011

[3] Aldape KD(2017)Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy Mol Cell 66 141-53 e6

[4] Wrensch M(2018)Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy Biomaterials. 154 169-181

[5] Liu J(2007)Molecular understanding and modern application of traditional medicines: triumphs and trials Cell. 130 769-774

[6] Lee J(2014)Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer Carcinogenesis. 35 905-914

[7] Salazar Hernandez MA(2016)Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction Blood. 127 1173-1182

[8] Mazitschek R(2009)Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study Chin Med J 122 1666-1673

[9] Ozcan U(2008)Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression Cancer Lett 264 101-106

[10] Hu M(2014)Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network J Neurochem 128 256-266

[1] Schwartzbaum JA(2006)Epidemiology and molecular pathology of glioma Nat Clin Pract Neurol 2 494-503

[2] Fisher JL(2015)Treatment of obesity with celastrol Cell. 161 999-1011

[3] Aldape KD(2017)Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy Mol Cell 66 141-53 e6

[4] Wrensch M(2018)Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy Biomaterials. 154 169-181

[5] Liu J(2007)Molecular understanding and modern application of traditional medicines: triumphs and trials Cell. 130 769-774

[6] Lee J(2014)Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer Carcinogenesis. 35 905-914

[7] Salazar Hernandez MA(2016)Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction Blood. 127 1173-1182

[8] Mazitschek R(2009)Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study Chin Med J 122 1666-1673

[9] Ozcan U(2008)Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression Cancer Lett 264 101-106

[10] Hu M(2014)Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network J Neurochem 128 256-266