Pharmacologic therapy of osteoarthritis.

被引：3
作者：
Pelletier J.P. [1 ]
Choquette D. [1 ]
Haraoui B. [1 ]
Raynauld J.P. [1 ]
Rich E. [1 ]
Fernandes J.C. [1 ]
Martel-Pelletier J. [1 ]
机构：
[1] Osteoarthritis Research Unit, Centre Hospitalier de l'Universit de Montreal (CHUM), Hopital Notre-Dame, 1560 Sherbrooke St. E., H2L 4M1, Montreal, Quebec
来源：
Current Rheumatology Reports | 1999年 / 1卷 / 1期
关键词：
Osteoarthritis; Hyaluronic Acid; Capsaicin; Tenoxicam; Osteoarthritis Cartilage;
D O I：
10.1007/s11926-999-0026-0
中图分类号：
学科分类号：
摘要：
This article presents a brief review of the most current therapies that are used for the relief of the symptoms related to osteoarthritis. The agents used either systematically or locally are described, providing the rationale for their usage in the treatment of osteoarthritis. Moreover, new therapies that have reached clinical evaluations and that can possibly reduce or stop the progression of the disease--namely the inhibitors of metalloproteases--are presented. Overall, it is obvious that significant progress has been made toward the development of new therapeutic agents to reduce the symptoms as well as the structural changes of the disease.
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页码：54 / 58
页数：4
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  • [1] Felson DT(1998)An update on the epidemiology of knee and hip osteoarthritis with a view to prevention Arthritis Rheum 41 1343-1355
  • [2] Zhang Y(1997)Osteoarthritis Lancet 350 503-508
  • [3] Creamer P(1991)Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee N Engl J Med 325 87-91
  • [4] Hochberg MC(1997)A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen Scand J Gastroenterol 32 126-130
  • [5] Bradley JD(1997)Effect of celecoxib, a novel COX-2 inhibitor, on health-related quality of life of patients with osteoarthritis of the knee Arthritis Rheum 40 S88-S88
  • [6] Brandt KD(1996)Molecular mechanisms implicated in the inhibition of collagenase expression by diacerhein Rev Prat 46 S15-S19
  • [7] Katz BP(1996)Beneficial effects of treatment with diacerhein in guinea pigs with osteoarthritis Rev Prat 46 S35-S39
  • [8] Bjarnason I(1994)Diacerhein in the treatment of osteoarthritis of the hip Arthritis Rheum 37 529-536
  • [9] Macpherson A(1988)Efficacy and tolerability of diacerhein in the treatment of osteoarthritis Curr Therap Res 43 878-887
  • [10] Rotman H(1989)Effects of unsaponifiable extracts of avocado/soy beans (PIAS) on the production of collagen by cultures of synoviocytes, articular chondrocytes and skin fibroblasts Rev Rhum Mal Osteoartic 56 207-211
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