Pax5: the guardian of B cell identity and function

被引：0
作者：
César Cobaleda
Alexandra Schebesta
Alessio Delogu
Meinrad Busslinger
机构：
[1] Research Institute of Molecular Pathology,
[2] Vienna Biocenter,undefined
[3] Present address: Universidad de Salamanca,undefined
[4] Campus Miguel de Unamuno,undefined
[5] 37007 Salamanca,undefined
[6] Spain.,undefined
来源：
Nature Immunology | 2007年 / 8卷
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摘要：
The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage 'inappropriate' genes and simultaneously activating B lineage–specific genes. This transcriptional reprogramming restricts the broad signaling capacity of uncommitted progenitors to the B cell pathway, regulates cell adhesion and migration, induces VH-DJH recombination, facilitates (pre-)B cell receptor signaling and promotes development to the mature B cell stage. Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B lymphopoiesis. PAX5 has also been implicated in human B cell malignancies, as it is deregulated by chromosomal translocations in a subset of acute lymphoblastic leukemias and non-Hodgkin lymphomas.
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页码：463 / 470
页数：7
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