Changing trends in the clinical course and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital

被引：19
作者：
Al-Shehri A. [1 ]
Jastaneiah S. [1 ]
Wagoner M.D. [1 ,2 ]
机构：
[1] Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh
[2] The Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA 52242-1091
来源：
International Ophthalmology | 2009年 / 29卷 / 3期
关键词：
Bacterial keratitis; Corticosteroids; Doxycycline; Fortified antibiotics; Medroxyprogesterone;
D O I：
10.1007/s10792-008-9206-6
中图分类号：
学科分类号：
摘要：
Objective: To evaluate changes in the predisposing factors and causative organisms, clinical course, and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital (KKESH) between 1995 and 2005. Methods: Retrospective review of 78 and 103 cases of culture-positive bacterial keratitis admitted to KKESH in 1995 and 2005. Main outcome measures: Microbiological cure, visual outcome. Results: There was little change in the predisposing factors for bacterial keratitis, initial clinical severity, or the microbiological profile between 1995 and 2005. While similar topical fortified antibiotic therapy regimens were used in both 1995 and 2005, there was a significant increase in the use of topical corticosteroids in 2005 (P < 0.001), either alone or in combination with medroxyprogesterone 1% and doxycycline. There were significant improvements in the percentage of eyes achieving microbiological cure with medical therapy alone (76.0 vs. 92.2%, P = 0.002) or in combination with surgical intervention (92.4 vs. 100.0%; P = 0.005). The percentage of eyes requiring enucleation or evisceration due to treatment failure declined significantly from 7.6 to 0% (P = 0.006). There was a significant improvement in the percentage of eyes achieving a final visual acuity ≥20/40 (10.1 vs. 29.1%, P = 0.001). Conclusions: Significantly better clinical outcomes were achieved in 2005 compared to 1995. Increased emphasis on management of inflammation in conjunction with the infectious process may have contributed to the improved outcomes. © Springer Science+Business Media B.V. 2008.
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页码：143 / 152
页数：9
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