Progressive Disseminated Histoplasmosis and HIV/AIDS: a Dermatological Perspective

被引：1

作者：

Chang P. ^{[1
]}

Meaux T. ^{[1
,2
]}

机构：

[1] Dermatology Service Social Security General Hospital—IGSS, 9ª. Street 7-55 Zone 9, Guatemala City

[2] Dermatology Elective, Hospital General de Enfermedades IGSS, 9ª. Street 7-55 Zone 9, Guatemala City

来源：

Current Fungal Infection Reports | 2015年 / 9卷 / 4期

关键词：

Cutaneous; Dissemination; Histoplasma capsulatum; Histoplasmosis; HIV; PDH; immunosuppression; Progressive disseminated histoplasmosis;

D O I：

10.1007/s12281-015-0233-2

中图分类号：

学科分类号：

摘要：

Progressive disseminated histoplasmosis (PDH) occurs as a result of internal spread of Histoplasma capsulatum from the lungs to organs rich in monocytes. This typically occurs in immunosuppressed patients, such as those with HIV/AIDS. Skin involvement is found in 10 % of all patients with PDH in the USA and in up to 25 % of those with AIDS. Crusted papular or plaque-like lesions are most common, with others being nodular, pustular, ulcerated, vegetative, acneiform, or wart-like. Lesions may be caused by the fungus itself or an immune response to the infection, such as erythema nodosum or erythema multiform. Histopathology demonstrates necrosis of the superficial dermal vessels. The differential diagnosis is broad and varies depending on the location and morphology of the lesion(s). Culture is the gold standard for diagnosis, and first-line treatment is amphotericin B for 1–2 weeks at a dose of 3 mg/kg/day. © 2015, Springer Science+Business Media New York.

引用

页码：213 / 219

页数：6

共 36 条

[1]

Deepe G.S., Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases 7th ed [Ebook], Churchill Livingston Elsevier

[2]

2010

[3]

chapter, 264, pp. 3305-3318

[4]

Adenis A., Nacher M., Hanf M., Basurko C., Dufour J., Huber F., Et al., Tuberculosis and histoplasmosis among human immunodeficiency virus-infected patients: a comparative study, Am J Trop Med Hyg, 90, pp. 216-223, (2014)

[5]

Harnalikar M., Kharkar V., Khopkar U., Disseminated cutaneous histoplasmosis in an immunocompetent adult, Indian J Dermatol, 57, pp. 206-209, (2012)

[6]

Shirali A., Jyoti K., Vupputuri A., Kuruvila M., Prabhu M.V., Disseminated histoplasmosis with conjunctival involvement in an immunocompromised patient, Indian J Sex Transm Dis, 31, pp. 35-38, (2010)

[7]

Pal J., Ray A.N., Sherp P., Majumdar B.B., Modak D., Chatterjee S., Et al., Primary cutaneous histoplasmosis simulating Molluscum contagiosum, J Assoc Physicians India, 61, pp. 498-500, (2013)

[8]

Pal N., Adhikary M., Cutaneous histoplasmosis in a HIV seronegative patient, J Nat Sci Biol Med, 4, pp. 477-479, (2013)

[9]

Bonifaz A., Chang P., Moreno K., Fernandez-Fernandez V., Montes de Oca G., Araiza J., Et al., Disseminated cutaneous histoplasmosis in acquired immunodeficiency syndrome: report of 23 cases, Clin Exp Dermatol, 34, pp. 481-486, (2009)

[10]

Dhawan J., Verma P., Sharma A., Ramam M., Kabra S.K., Gupta S., Disseminated cutaneous histoplasmosis in an immunocompetent child, relapsed with itraconazole, successfully treated with voriconazole, Pediatr Dermatol, 27, pp. 549-551, (2010)

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