Allosteric control of the ribosome by small-molecule antibiotics

被引：0
|
作者：
Leyi Wang
Arto Pulk
Michael R Wasserman
Michael B Feldman
Roger B Altman
Jamie H Doudna Cate
Scott C Blanchard
机构：
[1] Weill Cornell Medical College,Department of Physiology and Biophysics
[2] University of California at Berkeley,Department of Molecular and Cell Biology
[3] University of California at Berkeley,Department of Chemistry
[4] Weill Cornell Medical College,Physical Biosciences Division
[5] Rockefeller University,undefined
[6] Memorial Sloan-Kettering Cancer Center Tri-Institutional MD/PhD Program,undefined
[7] Lawrence Berkeley National Laboratory,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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摘要：
Antibiotics target protein synthesis by binding and inhibiting key functional centers of the ribosome. Single-molecule imaging and X-ray crystallography studies now demonstrate that the aminoglycoside antibiotic neomycin binds to ribosomal RNA within the large subunit to allosterically control ribosomal subunit rotation and stabilize an inactive configuration of the ribosome.
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页码：957 / 963
页数：6
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