Synthesis and antifungal activity of novel α-alkoxyimino-(1H-benzoimidazol-2-yl)acetonitriles containing piperazine moiety

被引：0
作者：
Qingdong Jin
Fubo Li
Ying Li
Fei Jin
Lin Jiang
机构：
[1] Shandong Agricultural University,College of Plant Protection
[2] Shandong Agricultural University,College of Chemistry and Material Science
来源：
Research on Chemical Intermediates | 2015年 / 41卷
关键词：
Benzimidazole; Alkoxyimine; Piperazine; Synthesis; Antifungal activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of α-alkoxyimino-[1-(4-methylpiperazino-1-yl)carbonylmethyl-1H-benzimidazol-2-yl] acetonitriles were synthesized from o-phenylenediamine, ethyl cyanoacetate, chloroacetyl piperazine, and haloalkane/benzyl chloride by multi-step reactions. The structures of the target compounds were elucidated by IR, 1H NMR, MS, and elemental analysis. All the target compounds were tested for in vitro antifungal activities against Sclerotinia sclerotiorum and Botrytis cinerea by the mycelium growth rate method, and the results indicated that some compounds displayed higher antifungal activity as compared to carbendazim.
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页码：7695 / 7702
页数：7
相关论文
共 67 条
[1]  
Zhang PZ(2012)undefined Chin. Chem. Lett. 23 1381-1384
[2]  
Zhou SF(2012)undefined Eur. J. Med. Chem. 53 41-51
[3]  
Li TR(2012)undefined Res. Chem. Intermed. 38 2523-2545
[4]  
Jiang L(2010)undefined Eur. J. Med. Chem. 45 5856-5861
[5]  
Patel RV(2014)undefined Eur. J. Med. Chem. 76 494-505
[6]  
Patel PK(2013)undefined Med. Chem. Res. 22 5077-5104
[7]  
Kumari P(2011)undefined Pest Manag. Sci. 67 191-198
[8]  
Rajani DP(2014)undefined Bioorg. Med. Chem. Lett. 24 2173-2176
[9]  
Chikhalia KH(2010)undefined Bioorg. Med. Chem. Lett. 20 4693-4699
[10]  
Abu-Bakr SM(2011)undefined Aust. J. Chem. 64 367-372
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