Mechanisms of tissue injury in lupus nephritis

被引：0
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作者：
Tamara K Nowling
Gary S Gilkeson
机构：
[1] Medical University of South Carolina,Department of Medicine, Division of Rheumatology
[2] Ralph H. Johnson Veterans Affairs Medical Center,Medical Research Service
来源：
Arthritis Research & Therapy | / 13卷
关键词：
Nephritis; Systemic Lupus Erythematosus Patient; Lupus Nephritis; Membrane Attack Complex; iNOS Activity;
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摘要：
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.
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