Role of Xenobiotic Metabolism Enzyme Gene Polymorphism in the Formation of Chemotherapy Resistance in Patients with Chronic Lymphoproliferative Diseases

被引：0
作者：
E. A. Gorbachenko
O. B. Goreva
N. P. Domnikova
A. Yu. Grishanova
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Institute of Molecular Biology and Biophysics
[2] Siberian Division of the Russian Academy of Medical Sciences,Institute of Regional Pathology and Pathomorphology
来源：
Bulletin of Experimental Biology and Medicine | 2013年 / 155卷
关键词：
enzymes of xenobiotic metabolism; chronic lymphoproliferative diseases; chemotherapy resistance; gene polymorphism;
D O I：
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摘要：
Enzymes of the cytochrome P450 and GSTP1 families play a pivotal role in the metabolism of a wide variety of antitumor drugs and polymorphisms of genes encoding for metabolizing enzymes can affect drug efficacy and toxicity. We studied the associations between functionally significant gene polymorphisms CYP2C8, CYP2C9, CYP2C19, CYP3A5, and GSTP1 and clinical response to chemotherapy in patients with chronic lymphoproliferative diseases. Significant correlations with chemotherapy resistance were observed for CYP2C8*3 (OR=7.05; CI 95%=1.76-29.55) and CYP2C9*2 polymorphisms (OR=4.1; CI 95%=1.03-16.81). No significant association between chemotherapy resistance and other examined polymorphisms were found.
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页码：676 / 679
页数：3
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