Management of Actinic Keratosis

被引：0

作者：

Bhatia N. ^{[1
]}

机构：

[1] Therapeutics Clinical Research, San Diego, CA

来源：

Current Dermatology Reports | 2017年 / 6卷 / 4期

关键词：

Actinic; Carcinoma; Chemoprevention; Keratosis; Photodamage; Photodynamic;

D O I：

10.1007/s13671-017-0206-5

中图分类号：

学科分类号：

摘要：

Purpose of Review: Approaching treatment for actinic keratosis must start with defining the disease, often as a point in a spectrum of disease between normal skin and progression of cumulative photoexposure. With many of the available topical therapies, dermatologists are fixated on reactions and not on outcomes, which influences patient expectations and long-term strategies, instead of understanding the mechanisms of action of therapies, integration into combination regimens with lesional destruction, and long-term maintenance to reduce skin cancer risks. Recent Findings: New vehicles and percentages of active ingredients, new photodynamic therapy protocols, and systemic chemoprevention with nicotinamide and retinoids are also going to be reviewed in this article. Summary: Considerations for treatment of actinic keratoses start with answers to questions about SCC and the greater assessment of the precursor disease of photodamage. © 2017, Springer Science+Business Media, LLC.

引用

页码：279 / 287

页数：8

共 47 条

[31]

Bhatia N., Et al., Understanding the role of photolyases: photoprotection and beyond, J Drugs Dermatol, 16, pp. s61-s66, (2017)

[32]

Eibenschutz L., Silipo V., Milani M., Catricala C., A 9 month, randomized, assessor-blinded, parallel group study to evaluate the clinical effects of a film-forming medical devices containing photolyase in the treatment of cancerization field in comparison with sunscreen in patients after successful PDT for actinic keratosis, presented as poster 24th EADV, (2015)

[33]

Vidal-Asensi S., Et al., Photolyase sunscreen (Eryfotona®) decreases expression of p53 and Ki67 in comparison to standard 50+ SPF, J Am Acad Dermatol, 66, (2012)

[34]

Nowis, Et al., The influence of photodynamic therapy on the immune response, Photodiagn Photodyn Ther, 2, pp. 283-298, (2005)

[35]

Willey A., Et al., Temperature-modulated photodynamic therapy for the treatment of actinic keratosis on the extremities: a one-year follow-up study, Dermatol Surg, 41, pp. 1290-1295, (2015)

[36]

Clementoni M., Roscher M., Munavalli G., Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light, Lasers Surg Med, 42, 2, pp. 150-159, (2010)

[37]

Mikolajewska P., Et al., Microneedling of human skin improves 5-ALA and 5-MAL-induced PpIX production for topical PDT without increase in pain or erythema, Pharm Res, 27, pp. 2213-2220, (2010)

[38]

Maisch T., Et al., Fluorescence induction of Protoporphyrin IX by a new 5-Aminolevulinic acid Nanoemulsion used for photodynamic therapy in a full-thickness ex vivo skin model, Exp Dermatol, 19, 8, pp. e302-e305, (2010)

[39]

Dirschka T., Et al., Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind, phase III study in comparison with a registered methyl 5-aminolaevulinate cream and placebo, Br J Dermatol, 166, pp. 137-146, (2012)

[40]

Stasko T., Et al., Guidelines for the Management of Squamous Cell Carcinoma in organ transplant recipients, Dermatol Surg, 30, 4, pp. 642-650, (2004)

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